摘要
目的探讨扩散加权成像(DWI)表观扩散系数(ADC)值与乳腺癌患者半乳糖凝集素-3(Gal-3)、p53蛋白关系及预测TP化疗(多西他赛+卡铂)效果。方法选取2019年10月—2021年10月承德医学院附属医院收治的143例乳腺癌(研究组)、72例乳腺良性肿瘤(良性组)及75例健康体检者(健康组)DWI参数[计算表观弥散系数最小值(ADCmin)、表观扩散系数平均值(ADCmean)]及其与组织Gal-3、p53蛋白相关性,绘制受试者工作曲线(ROC),分析DWI参数预测TP化疗效果。结果研究组ADCmin、ADCmean低于良性组、健康组,且良性组低于健康组(P<0.05)。不同肿瘤直径、病理分级、分化程度、Gal-3、p53蛋白患者ADCmin、ADCmean比较,差异有统计学意义(P<0.05)。ADCmin、ADCmean与肿瘤直径、病理分级、分化程度、Gal-3、p53蛋白呈负相关(P<0.05)。化疗后有效患者ADCmin、ADCmean及差值大于无效患者(P<0.05)。绘制ROC曲线显示,ADCmin、ADCmean差值预测乳腺癌患者TP化疗效果的AUC分别为0.769(95%CI:0.692~0.836)、0.726(95%CI:0.645~0.797)。结论DWI参数与乳腺癌患者Gal-3、p53蛋白呈负相关,且对TP化疗效果具有一定预测价值。
Objective To investigate the relationship between apparent diffusion coefficient(ADC)value of diffusion-weighted imaging(DWI)and galactose lectin-3(Gal-3)and p53 protein in breast cancer patients,and to predict the effect of TP chemotherapy(docetaxel+carboplatin).Methods A total of 143 cases of breast cancer(study group),72 cases of benign breast tumors(benign group)and 75 cases of healthy physical examination subjects(healthy group)were selected from the Affiliated Hospital of Chengde Medical College from October 2019 to October 2021.DWI parameters[calculatedADCmin,ADCmean]and their correlation with tissue Gal-3 and p53 proteins were recorded,and receiver operating curve(ROC)was plotted to analyze DWI parameters to predict the chemotherapy effect of TP.Results The ADCmin and ADCmean of the study group were lower than those of the benign group and the healthy group,and the benign group was lower than the healthy group(P<0.05).There were significant differences in ADCmin and ADCmean among patients with different tumor diameter,pathological grade,differentiation degree,Gal-3 and p53 protein(P<0.05).ADCmin and ADCmean were negatively correlated with tumor diameter,pathological grade,differentiation degree,Gal-3 protein and p53 protein(P<0.05).After chemotherapy,the ADCmin,ADCmean and the difference were higher in effective patients than in ineffective patients(P<0.05).The ROC curve showed that the AUC of ADCmin and ADCmean difference in predicting the chemotherapy effect of TP in breast cancer patients was 0.769(95%CI:0.692-0.836)and 0.726(95%CI:0.645-0.797),respectively.Conclusion DWI parameters are negatively correlated with Gal-3 and p53 proteins in breast cancer patients,and have certain predictive value for the chemotherapy effect of TP.
作者
佟颖
米楠
张荣
张斌
邢千超
王爱辉
TONG Ying;MI Nan;ZHANG Rong;ZHANG Bin;XING Qianchao;WANG Aihui(Radiology Department,The Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China;Medical Equipment Division,The Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China;Department of Nuclear Medicine,The Affiliated Hospital of Chengde Medical University,Chengde 067000,Hebei,China;School of Nursing,Chengde Medical College,Chengde 067000,Hebei,China;Department of Orthopaedics,The 964th Hospital,Changchun 130000,Jilin,China)
出处
《医学研究与战创伤救治》
CAS
北大核心
2023年第12期1272-1276,共5页
Journal of Medical Research & Combat Trauma Care
基金
河北省医学科研课题计划(20200389)。
