摘要
以分离自我国巴马长寿老人肠道菌群,且具有益生特性的乳双歧杆菌Bifidobacterium. animalis. subsp. Lactis. MN-Gup为研究对象,探究了该菌株在发酵乳中的发酵特性及MN-Gup发酵乳在贮藏期内的理化性质,同时采用高脂肪饮食和链脲佐菌素诱导二型糖尿病大鼠模型考察MN-Gup益生菌酸奶对血糖的调节作用。结果显示,MN-Gup益生菌酸奶在4℃冷藏条件下贮藏期内(28 d)可以保持较好的乳酸菌活菌数(>10^(8)CFU/g)及理化指标,且与普通酸奶相比,益生菌酸奶具有更优的感官评价喜好度,说明乳双歧杆菌MNGup具有良好发酵性能的同时可赋予发酵乳良好的特征风味。进而通过动物实验证实,MN-Gup益生菌酸奶可以显著降低二型糖尿病大鼠的空腹血糖和胰岛素抵抗水平,并促进体内胰高血糖素样肽-1的分泌,调节脂代谢,具有改善二型糖尿病临床症状的功效。
Probiotics Bifidobacterium.animalis.subsp.Lactis.MN-Gup,which was isolated from the intestinal flora of long-lived elderly people in Bama,China,was investigated for its fermentation characteristics in yogurt and physicochemical properties during storage.The regulation effect of MN-Gup probiotic yogurt on blood glucose was also explored using the type 2 diabetic rat model.The results showed that MN-Gup probiotic yogurt could maintain an acceptable number of viable lactic acid bacteria(>10^(8) CFU/g)and favorable physicochemical indicators during the storage period(28 days)at 4°C.Compared with conventional yogurt,the probiotic yogurt had better sensory evaluation preference,indicating that Bifidobacterium lactis MN-Gup had good fermentation performance and could endow yogurt with good characteristic flavor.Subsequently,the in vivo test results confirmed that MN-Gup probiotic yogurt could significantly reduce fasting blood glucose levels,improve insulin resistance,and modulate serum lipid profiles in HFD/STZ-treated rats,which had the potential to alleviate the clinical symptoms of type 2 diabetes.
作者
李树森
牛天娇
康小红
缪宇思
王然
任发政
肖然
LI Shusen;NIU Tianjiao;KANG Xiaohong;MIAO Yusi;WANG Ran;REN Fazheng;XIAO Ran(Mengniu Hi-Tech Dairy Product Beijing Co.Ltd.,Beijing 101100,China;Key Laboratory of Precision Nutrition and Food Quality,Department of Nutrition and Health,China Agricultural University,Beijing 100193,China)
出处
《中国乳品工业》
CAS
北大核心
2024年第1期22-27,52,共7页
China Dairy Industry
基金
内蒙古自治区科技计划项目资助(2020GG0111)。
关键词
乳双歧杆菌MN-Gup
益生菌酸奶
二型糖尿病
航天诱变菌株
血糖调节
Bifidobacterium.animalis.subsp.Lactis.MN-Gup
probiotics yogurt
type 2 diabetes
aerospace mutagenic strains
blood glucose regulation
