摘要
Erythroferrone是一种新发现的、调节人体铁稳态的重要因子,主要由成红细胞产生。Erythroferrone响应促红细胞生成素增加,并通过铁调素调节血浆铁水平及全身铁的吸收和利用,在铁代谢相关疾病的病理生理过程中起重要作用。慢性肾脏病并发肾性贫血患者存在促红细胞生成素不足和铁代谢紊乱,目前有关Erythroferrone在肾性贫血发病机制、治疗反应和预后中作用的研究尚不足。因此,深入探讨Erythroferrone在肾性贫血中的作用有助于提高对铁代谢紊乱相关疾病的认识,Erythroferrone也有望成为检测肾性贫血和评估治疗反应的一项生物学标志物。该文综述了Erythroferrone的生理功能及其在铁代谢与肾性贫血中的研究进展。
Erythroferrone is a newly discovered and important factor regulating iron homeostasis and mainly produced by erythroblasts.Erythroferrone responds to the increase of erythropoietin and regulates plasma iron level,along with the absorption and utilization of iron via hepcidin,which plays an important role in the pathophysiology of iron metabolism-related diseases.Erythropoietin deficiency and iron metabolism disturbance are prominent features of renal anemia complicated with chronic kidney disease.Accordingly,erythroferrone is corresponding to the pathogenesis,treatment and prognosis of renal anemia.The in-depth study contributes to the further understanding of the mechanism related to iron metabolism disorder,and erythroferrone is also expected to be used as a valuable biomarker in the detection of renal anemia and the evaluation of therapeutic response.The article systematically reviews the physiological function of erythroferrone and its research progress in iron metabolism and renal anemia.
作者
徐秋郁
陈罡
李雪梅
Xu Qiuyu;Chen Gang;Li Xuemei(Chinese Academy of Medical Science&Peking Union Medical College,Internal Medicine Department,Peking Union Medical College Hospital,Beijing 100730,China;Chinese Academy of Medical Science&Peking Union Medical College,Department of Nephrology,Peking Union Medical College Hospital,Beijing 100730,China)
出处
《中华肾脏病杂志》
CAS
CSCD
北大核心
2023年第12期951-956,共6页
Chinese Journal of Nephrology
基金
北京市自然科学基金(7232128)
协和学者与创新团队发展计划(2016)。
关键词
肾功能不全
慢性
贫血
铁代谢障碍
缺氧诱导因子
铁调素
Renal insufficiency,chronic
Anemia
Iron metabolism disorder
Hypoxia inducible factor
Hepcidin
