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头孢他啶联合曲美他嗪治疗老年心力衰竭合并肺部感染的疗效及对血清炎症因子水平、免疫功能的影响 被引量:1

Efficacy of Ceftazidime Combined with Trimetazidine in the Treatment of Senile Heart Failure Complicated with Lung Infection and Effect on Serum Inflammatory Factors and Immune Function
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摘要 目的研究头孢他啶联合曲美他嗪治疗老年心力衰竭合并肺部感染的疗效及对血清炎症因子水平、免疫功能的影响。方法以2020年7月至2022年12月河南大学第一附属医院收治的82例老年心衰合并肺部感染患者为研究对象,采用随机数字表法分为对照组和观察组,各41例。对照组采用曲美他嗪治疗,观察组采用头孢他啶联合曲美他嗪治疗。比较两组临床疗效,相关症状(咳嗽、气喘、发热、肺部湿啰音)消失时间,治疗前及治疗14 d后免疫功能指标(CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)),心肌损伤标志物[肌酸激酶(CK)、肌酸激酶同工酶(CKMB)、乳酸脱氢酶(LDH)]水平,血清炎症介质[白细胞介素-1β(IL-1β)、降钙素原(PCT)、CD40L配体(CD40L)、S100钙结合蛋白A12(S100A12)]水平及不良反应发生率。结果观察组临床总有效率(92.68%)高于对照组(75.61%)(P<0.05),观察组咳嗽、气喘、发热、肺部湿啰音消失时间均短于对照组(P<0.05)。治疗14 d后,观察组CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组(P<0.05);观察组CK、CKMB、LDH水平低于对照组(P<0.05);观察组血清IL-1β、PCT、CD40L、S100A12水平低于对照组(P<0.05)。两组不良反发生率比较,差异无统计学意义(P>0.05)。结论采用头孢他啶与曲美他嗪联合治疗老年心衰合并肺部感染患者可显著提高临床疗效,抑制炎症反应及心肌损伤,减轻临床症状,促进免疫功能改善。 Objective To investigate the efficacy of ceftazidime combined with trimetazidine in the treatment of senile heart failure complicated with lung infection and the effects on serum inflammatory factors and immune function.Methods A total of 82 elderly patients with heart failure combined with pulmonary infection admitted to The First Affiliated Hospital of Henan University from July 2020 to December 2022 were selected as the research objects.They were divided into control group and observation group by random number table method,with 41 cases in each group.The control group was treated with trimetazidine,and the observation group was treated with ceftazidime combined with trimetazidine.Compare the clinical efficacy and related symptom disappearance time(cough,wheezing,fever,lung moist rales)of the two groups,the immune function indicators(CD3^(+),CD4^(+),CD4^(+)/CD8^(+)),myocardial injury marker levels[creatine kinase(CK),creatine kinase isoenzyme(CKMB),lactate dehydrogenase(LDH)],serum inflammatory mediator levels[interleukin-1β(IL-1β),procalcitonin(PCT),CD40L ligand(CD40L),S100 calcium-binding protein A12(S100A12)]before and after 14 days of treatment,and the incidence of adverse reactions between the two groups.Results The total effective rate of observation group(92.68%)was higher than that of control group(75.61%)(P<0.05).The disappearance time of cough,asthma,fever and pulmonary wet rales in the observation group was shorter than that in the control group(P<0.05).After 14 days of treatment,CD3^(+),CD4^(+),CD4^(+)/CD8^(+)in the observation group were higher than those in the control group(P<0.05);CK,CKMB and LDH levels in observation group were lower than those in control group(P<0.05);the levels of IL-1β,PCT,CD40L and S100A12 in the observation group were lower than those in the control group(P<0.05).There was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ceftazidime combined with trimetazidine in the treatment of elderly patients wi
作者 王艳娟 刘湾 刘朝辉 杨彦伟 杨铭霞 WANG Yanjuan;LIU Wan;LIU Chaohui;YANG Yanwei;YANG Mingxia(The First Affiliated Hospital of Henan University,Kaifeng Henan 475000,China)
出处 《药品评价》 CAS 2023年第10期1270-1273,共4页 Drug Evaluation
基金 2019年河南省医学科技攻关计划联合共建项目(LHGJ20190502)。
关键词 心力衰竭 头孢他啶 曲美他嗪 老年人 肺部感染 疗效 Heart failure Ceftazidime Trimetazidine Aged Lung infection Curative effect
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