摘要
目的:观察肺结核伴糖尿病患者血糖控制效果与抗结核疗效的关联性。方法:回顾性分析2022年4月至2023年4月该院收治的130例肺结核伴糖尿病患者的临床资料,所有患者均给予统一降血糖治疗,根据患者的血糖控制效果将其分为良好组、尚可组和较差组,均给予三组统一抗结核治疗方案。比较三组抗结核治疗效果、痰菌转阴率、病灶吸收率和T细胞亚群指标(CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+))水平。结果:良好组抗结核治疗总有效率为100.00%(58/58),明显高于尚可组的82.05%(32/39)和较差组的66.67%(22/33),差异有统计学意义(P<0.05);良好组痰菌转阴率和病灶吸收率均高于尚可组和较差组,差异有统计学意义(P<0.05);治疗后,三组CD4^(+)、CD4^(+)/CD8^(+)水平均高于治疗前,且良好组高于尚可组和较差组,尚可组高于较差组,三组CD8^(+)水平均低于治疗前,且良好组低于尚可组和较差组,尚可组低于较差组,差异有统计学意义(P<0.05)。结论:血糖控制效果,肺结核伴糖尿病患者的抗结核疗效也较好。
Objective:To observe correlation between blood glucose control effect and anti-tuberculosis efficacy in patients with pulmonary tuberculosis and diabetes mellitus.Methods:The clinical data of 130 patients with pulmonary tuberculosis and diabetes mellitus admitted to this hospital from April 2022 to April 2023 were retrospectively analyzed.All patients were given unified hypoglycemic therapy.According to the level of blood glucose control,those patients were divided into good group,fair group and poor group.All three groups were given a unified anti-tuberculosis treatment plan.The anti-tuberculosis treatment effect,the sputum negative conversion rate,the lesion absorption rate,and the T cell subsets(CD4^(+),CD8^(+),CD4^(+)/CD8^(+))levels were compared among the three groups.Results:The total effective rate of anti tuberculosis treatment of the good group was 100.00%(58/58),which was significantly higher than 82.05%(32/39)of the fair group and 66.67%(22/33)of the poor group,and the differences were statistically significant(P<0.05).The sputum negative conversion rate and the lesion absorption rate in the good group were higher than those in the fair group and the poor group,and the differences were statistically significant(P<0.05).After the treatment,the levels of CD4^(+)and CD4^(+)/CD8^(+)in the three groups were higher than those before the treatment,those in the good group were higher than those in the fair group and the poor group,and those in the fair group were higher than those in the poor group;the levels of CD8^(+)in the three groups were lower than those before the treatment,that in the good group was lower than that in the fair group and poor group,that in the fair group was lower than that in the poor group;and the differences were statistically significant(P<0.05).Conclusions:The blood sugar control effect is good,and the anti tuberculosis effect of patients with pulmonary tuberculosis and diabetes is also good.
作者
姚晓迪
YAO Xiaodi(Third Department of Tuberculosis of Third People’s Hospital of Pingdingshan City,Pingdingshan 467000 Henan,China)
出处
《中国民康医学》
2024年第2期156-158,共3页
Medical Journal of Chinese People’s Health
关键词
肺结核
糖尿病
抗结核疗效
血糖
关联性
Pulmonary tuberculosis
Diabetes
Anti-tuberculosis efficacy
Blood glucose
Correlation
