摘要
大量研究表明中药大黄在治疗脓毒症方面具有较好效果,为进一步明确大黄治疗脓毒症的相关作用及机制,本研究从脓毒症的中医学认识、脓毒症对肠道菌群的负面影响、肠道菌群调节在脓毒症治疗中的意义及大黄通过调节肠道菌群治疗脓毒症几方面进行综述。研究发现,脓毒症的发生、发展与肠道菌群的改变密切相关,单药大黄、大黄复方及大黄单体均可有效治疗脓毒症,其作用机制可能与改善肠道菌群失调、保护胃肠黏膜屏障、阻止肠道细菌移位与内毒素吸收入血、减少炎症反应等有关。本综述进一步明确大黄对脓、毒症的治疗作用及其相关机制,为其在临床上防治脓毒症提供理论依据。
A lot of studies have shown that Rhei Radix Et Rhizoma has good efficacy in the treatment of sepsis.In order to further clarify the related role and mechanism of Rhei Radix Et Rhizoma in the treatment of sepsis,this paper reviews the understanding of sepsis in traditional Chinese medicine,the negative effect of sepsis on intestinal flora,the significance of intestinal flora regulation in the treatment of sepsis,and the effect of Rhei Radix Et Rhizoma on sepsis by regulating intestinal flora.Studies have found that the occurrence and development of sepsis is closely related to the changes of intestinal flora.Single drug Rhei Radix Et Rhizoma,Rhei Radix Et Rhizoma compound and Rhei Radix Et Rhizoma monomer can effectively treat sepsis,and its mechanism may be related to improving intestinal flora imbalance,protecting gastrointestinal mucosal barrier,preventing intestinal bacterial translocation,and endotoxin absorption into the blood,and reducing inflammatory response.This review further clarified the therapeutic effect of Rhei Radix Et Rhizoma on sepsis and its related mechanism,and provided a theoretical basis for the clinical prevention and treatment of sepsis.
作者
戴璇
陈少裕
李京心
张梦颖
孙燕妮
程记伟
DAI Xuan;CHEN Shaoyu;LI Jingxin;ZHANG Mengying;SUN Yanni;CHENG Jiwei(Department of Neurology,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Department of Emergency Internal Medicine,Putuo Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 200062,China;Department of Emergency,Shanghai Baoshan District Wusong Central Hospital,Shanghai 200940,China)
出处
《中国医药导报》
CAS
2023年第36期41-45,共5页
China Medical Herald
基金
国家自然科学基金资助项目(81573901)
成都中医药大学“杏林学者”学科人才科研提升计划项目(YYZX2022170)。
关键词
脓毒症
肠道菌群
大黄
综述
Sepsis
Intestinal flora
Rhei Radix Et Rhizoma
Review
