摘要
慢性阻塞性肺疾病(COPD)是最常见的慢性肺系疾病之一。而骨质疏松症(OP)是COPD最常见的合并症之一。近年来,肠道菌群(GM)与人体健康关系的研究日益深入,其与COPD合并骨质疏松症的发生、发展也引发了广泛关注。2000年第五次全国人口普查,我国进入老龄化阶段。老年人作为COPD合并骨质疏松症的主要发病群体,人口比例不断上升,探索COPD合并骨质疏松症的优化治疗方案成为临床及科研人员们的关注重点。以“肺与大肠相表里”为基础的“肺-肠”轴理论亦成为新的研究热点。本文基于“肺-肠”轴理论,根据COPD合并骨质疏松症的生理、病理特点,探讨调节肠道菌群在干预此类疾病中的重要性,旨在为COPD合并骨质疏松症患者探索新的防治思路,为进一步临床研究和推广提供理论支持。
Chronic obstructive pulmonary disease(COPD)is one of the most common chronic lung diseases.Osteoporosis(OP)is one of the most common complications of COPD.In recent years,the relationship between gut mi-crobiota(GM)and human health has been studied more and more deeply,and the occurrence and development of GM combined with COPD and osteoporosis has also attracted wide attention.According to the fifth national population cen-sus in 2000,our country entered the aging stage.The elderly population is the main morbidity group of COPD combined with osteoporosis,and its proportion is increasing.Exploring the optimal treatment plan of COPD combined with osteo-porosis has become the focus of clinical and scientific researchers.The"lung-intestine"axis theory based on"Exterior-in-terior Relationship between the Lung and the Large Intestine"has become a new research hotspot.Based on the"lung-gut"axis theory and the physiological and pathological characteristics of COPD complicated with osteoporosis,this paper discusses the importance of regulating intestinal flora in the intervention of such diseases,aiming to explore new prevention and treatment ideas for patients with COPD complicated with osteoporosis and provide theoretical sup-port for further clinical research and promotion.
作者
田小亚
赵榕
王娟
牛彩琴
叶震中
TIAN Xiao-ya;ZHAO Rong;WANG Juan;NIU Cai-qin;YE Zhen-zhong(North Sichuan Medical College,Nanchong 637000,Sichuan,CHINA;the Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,Sichuan,CHINA)
出处
《海南医学》
2024年第2期290-295,共6页
Hainan Medical Journal
基金
四川省中医药管理局面上项目(编号:2023MS340)
四川省南充市市校合作科研项目(编号:22SXQT0150)。
关键词
慢性阻塞性肺疾病
骨质疏松症
肠道菌群
肺-肠轴
综述
Chronic obstructive pulmonary disease
Osteoporosis
Intestinal flora
Lung-intestinal axis
Review
