摘要
目的探讨在原发性肝癌(PLC)姑息治疗中应用柴胡化积汤联合经肝动脉化疗栓塞术(TACE)治疗的效果。方法选取2021年1月至2022年6月江西省九江市第一人民医院收治的78例PLC患者作为研究对象,按照随机数字表法分为对照组(39例)和观察组(39例)。对照组采用TACE治疗,观察组加用柴胡化积汤治疗。比较两组患者的临床疗效、中医证候积分、免疫功能、生活质量及不良反应。结果观察组患者临床总有效率高于对照组,差异有统计学意义(P<0.05);两组患者治疗前中医证候积分、白细胞分化抗原(CD)CD3^(+)、CD4^(+)、CD8^(+)、CD4^(+)/CD8^(+)、循环免疫复合物(CIC)、癌症患者生活质量测定量表(QLQ-C30)比较,差异无统计学意义(P>0.05);观察组患者治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)、QLQ-C30评分高于对照组,中医证候积分、CD8^(+)、CIC低于对照组,差异有统计学意义(P<0.05);观察组患者不良反应发生率低于对照组,差异有统计学意义(P<0.05)。结论PLC姑息治疗中应用柴胡化积汤联合TACE治疗效果较佳,利于提高患者免疫功能及生活质量,缓解临床症状,安全性好,值得推广。
Objective To explore the efficacy of Chaihu Huaji Decoction combined with transarterial chemoembolization(TACE)in the palliative treatment of primary liver cancer(PLC).Methods A total of 78 PLC patients admitted to the First People's Hospital of Jiujiang,Jiangxi Province from January 2021 to June 2022 were selected as the study subjects.They were divided into a control group(39 cases)and an observation group(39 cases)using random number table method.The control group was treated with TACE,while the observation group was treated with Chaihu Huaji Decoction.Compare the clinical efficacy,traditional Chinese medicine(TCM)syndrome score,immune function,quality of life,and adverse reactions between the two groups.Results The total clinical effective rate of the observation group was higher than that of the control group,and the difference was statistically significant(P<0.05).There were no statistically significant differences(P>0.05)in the scores of TCM syndromes,cluster of differentiation(CD)CD3^(+),CD4^(+),CD8^(+),CD4^(+)/CD8^(+),circulating immune complex(CIC),and quality of life questionnaire core 30(QLQ-C30)of cancer patients between the two groups before treatment.After treatment,the CD3^(+),CD4^(+),CD4^(+)/CD8^(+),and QLQ-C30 scores in the observation group were higher than those in the control group,while the TCM syndrome score,CD8^(+),and CIC were lower than those in the control group,with statistical significances(P<0.05).The incidence of adverse reactions in the observation group was lower than that in the control group,and the difference was statistically significant(P<0.05).Conclusion The combination of Chaihu Huaji Decoction and TACE is more effective in palliative treatment of PLC,which is beneficial for improving immune function and quality of life,alleviating clinical symptoms,and has good safety.It is worth promoting.
作者
熊日晖
袁国辉
赵新华
XIONG Rihui;YUAN Guohui;ZHAO Xinhua(Department of Hepatobiliary Pancreatology,the First People's Hospital of Jiujiang,Jiangxi Province,Jiujiang332000,China)
出处
《中国当代医药》
CAS
2024年第3期104-107,111,共5页
China Modern Medicine
基金
江西省中医药管理局科技项目(2021B253)。
