摘要
目的探讨注射用重组人脑利钠肽对急性心力衰竭心功能指标、再入院率及炎症因子的影响。方法收集郑州大学第五附属医院2021年7月至2022年7月收治的90例急性心力衰竭患者进行研究,按随机数字表法分为两组。对照组45例接受吸氧、洛尔类药物、利尿药物、普利类药物、低盐饮食、强心剂等治疗。观察组45例在前基础上加注射用重组人脑利钠肽治疗。观察两组疗效、心功能指标[左室射血分数(LVEF)、心脏指数(CI)、心排血量(CO)]、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、超敏C反应蛋白(hs-CRP)、N端B型钠尿肽前体(NT-proBNP)、转化生长因子-β1(TGF-β1)水平、再入院率、心率、不良反应发生率。结果观察组总有效率高于对照组(P<0.05)。干预后两组心功能指标(LVEF、CI、CO)水平提高,观察组高于对照组(P<0.05)。干预后两组IL-6、TGF-β1、NT-proBNP、hs-CRP、TNF-α水平降低,观察组低于对照组(P<0.05)。观察组再入院率、心率低于对照组(P<0.05)。两组不良反应发生率差异无统计学意义(P>0.05)。结论注射用重组人脑利钠肽可改善急性心力衰竭患者的心功能,减轻炎症反应,并且能降低患者再入院率。
Objective To explore the effects of recombinant human brain natriuretic peptide for injection on cardiac function index,readmission rate and inflammatory factors in acute heart failure.Methods A total of 90 patients with acute heart failure admitted to the Fifth Affiliated Hospital of Zhengzhou University from July 2021 to July 2022 were studied and divided into two groups according to random number table method.The control group of 45 cases received oxygen inhalation,prolol drugs,diuretic drugs,pulliform drugs,low salt diet,cardiac tonic and other treatment.Observation group 45 cases were treated with recombinant human brain natriuretic peptide for injection on the basis of control group.Efficacy,cardiac function indexes[Left ventricular ejection fraction(LVEF),cardiac index(CI),cardiac output(CO)],tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),hypersensitive C-reactive protein(hs-CRP),N-terminal portion of proBNP(NT-proBNP),transforming growth factor beta 1(TGF-β1)level,readmission rate,heart rate and occurrence of adverse reactions of the two groups were observed.Results The total effective rate of the observation group was higher than that of the control group(P<0.05).Compared with before intervention,the levels of cardiac function indexes(LVEF,CI,CO)were increased after intervention,and the observation group was higher than the control group(P<0.05).After intervention,the levels of IL-6,TGF-β1,NT-proBNP,hs-CRP and TNF-αwere decreased,and the observation group was lower than the control group(P<0.05).Compared with the control group,the readmission rate and heart rate of the observation group were decreased(P<0.05).There was no significant difference in the incidence of adverse reactions between the observation group and the control group(P>0.05).Conclusion Recombinant human brain natriuretic peptide for injection improves cardiac function,reduces inflammation,and reduces readmission rates in patients with acute heart failure.
作者
户军燕
邱作栋
周宁
王淑娜
HU Junyan;QIU Zuodong;ZHOU Ning;WANG Shuna(Pharmacy Department,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China;Cardiology Department,the Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)
出处
《河南医学研究》
CAS
2024年第1期137-140,共4页
Henan Medical Research
关键词
注射用重组人脑利钠肽
急性心衰
心功能指标
炎症因子
recombinant human brain natriuretic peptide for injection
acute heart failure
cardiac function index
inflammatory factor
