摘要
目的探讨自拟四物润燥止痒合剂方口服、复方润燥乳膏外用联合自我管理干预(self-management interrention,SMI)模式的健康教育治疗老年皮肤瘙痒症(senile pruritus,SP)的临床疗效与安全性。方法将96例符合观察条件的老年皮肤瘙痒症患者按随机数字表法分为治疗组和对照组,每组48例。两组患者均采用相同的一般治疗,治疗组在一般治疗的基础上采用中西医结合三位一体综合干预治疗,自拟四物润燥止痒合剂方口服、复方润燥乳膏外涂患处联合自我管理干预模式的健康教育治疗;对照组在一般治疗的基础上采用口服氯雷他定片10mg 1次/天、尿素维生素E乳膏外涂患处治疗。2周为1个疗程,共观察2个疗程,治疗结束后随访6月。观察患者治疗前、中、后皮肤瘙痒程度、瘙痒对日常生活影响程度、瘙痒频率与持续时间、瘙痒发作时缓解方式的变化,评估两组临床疗效与不良反应发生情况。结果治疗组46例完成全程治疗和随访,对照组44例完成全程治疗和随访。治疗2周,治疗组皮肤瘙痒程度、瘙痒对日常生活影响程度、瘙痒频率与持续时间、瘙痒发作时缓解方式等相关症状总评分低于对照组,两组比较差异有统计学意义(差值1.50,95%CI 2.78~0.23,t=2.355,P=0.021,P<0.05)。治疗4周,治疗组皮肤瘙痒程度、瘙痒对日常生活影响程度、瘙痒频率与持续时间、瘙痒发作时缓解方式等相关症状总评分低于对照组,两组比较差异有统计学意义(差值2.77,95%CI 4.19~1.34,t=3.684,P=0.000,P<0.001)。治疗2周,治疗组总有效率为67.39%,对照组总有效率为45.45%,两组比较差异有统计学意义(χ^(2)=4.407,P=0.036,P<0.05)。治疗4周,治疗组总有效率为86.96%,对照组总有效率为65.91%,两组比较差异有统计学意义(χ^(2)=5.569,P=0.018,P<0.05)。治疗组不良反应发生率为6.52%(3/46),对照组不良反应发生率为11.36%(5/44),两组比较差异无统计学意义(校�
Objective To explore the clinical efficacy and safety of self-made Siwu Runzao Zhiyang mixture,compound Runzao cream and self-management intervention(SMI)in the treatment of senile skin pruritus(SP).Methods 96 patients with SP who met the observation conditions were randomly divided into treatment group and control group,with 48 cases in each group,the patients in both groups received the same general treatment,and the patients in the treatment group received a combination of TCM and a three-in-one intervention,a self-defined four-colored itch-killer solution,and a combination of the SMI model at the lateral cream application.Controls were treated with oral loratadine 10mg once a day and urea vitamin E cream application on the basis of general treatment.Two weeks was a course of treatment,and two courses were observed.The patients were followed up for 6 months after treatment.The degree of skin pruritus,the impact of pruritus on daily life,the frequency and duration of pruritus,and the changes of remission mode during the onset of pruritus were observed before,during and after treatment,and the clinical efficacy and adverse reactions of the two groups were evaluated.Results 46 cases in the treatment group completed the whole treatment and follow-up,and 44 cases in the control group completed the whole treatment and follow-up.After 2 weeks of treatment,the total scores of skin pruritus,the impact of pruritus on daily life,pruritus frequency and duration,and the remission mode of pruritus in the treatment group were lower than those in the control group.There was significant difference between the two groups(difference 1.50,95%CI 2.78~0.23,t=2.355,P=0.021,P<0.05).After 4 weeks of treatment,the total score of skin pruritus,the impact of pruritus on daily life,the frequency and duration of pruritus,the remission mode of pruritus and other related symptoms in the treatment group were lower than those in the control group.There was significant difference between the two groups(difference 2.77,95%CI 4.19~1.34,t=3.684,P=
作者
龙雄初
龙枚飞
刘小虎
王敏妨
周晓青
贾志霞
LONG Xiongchu;LONG Meifei;LIU Xiaohu;WANG Minfang;ZHOU Xiaoqing;JIA Zhixia(Emergency Department of the 81st Army Hospital of the PLA,Zhangjiakou 075000;Department of Pharmacy,Zhangjiakou Hospital of Traditional Chinese Medicine,Zhangjiakou 075000;Department of Geriatrics,Zhangjiakou Hospital of Traditional Chinese Medicine,Zhangjiakou 075000;Department of Geriatrics,Wentang Workers Sanatorium of Hebei Federation of Trade Unions,Pingshan 050402;Internal Medicine of Laoyazhuang Town Hospital,Zhangjiakou Economic Development Zone,Zhangjiakou 075000,China)
出处
《中国老年保健医学》
2023年第6期42-47,共6页
Chinese Journal of Geriatric Care
关键词
瘙痒症
老年人
中西医结合疗法
三位一体
senile pruritus
integrated traditional Chinese and western medicine
trinity method
