摘要
目的 探讨生长抑素(SS)联合甲磺酸加贝酯(GM)治疗高甘油三酯血症性急性胰腺炎(HTG-AP)的效果。方法 选择我院2019年5月至2023年5月收治的97例HTG-AP患者,分为SS组和SS+GM组,比较两组患者腹胀腹痛缓解时间、肛门恢复排气时间、血淀粉酶恢复正常时间、住院天数、住院费用、药物不良反应发生率,并比较两组患者治疗前后超敏C反应蛋白(CRP)、中性粒细胞-淋巴细胞比率(NLR)、血白细胞(WBC)变化情况。结果 SS+GM组患者腹胀腹痛缓解时间、肛门恢复排气时间、血淀粉酶恢复正常时间均短于SS组,差异有统计学意义(P <0.05)。治疗后两组患者CRP、NLR、WBC水平均较治疗前降低,且SS+GM组低于SS组,差异有统计学意义(P <0.05)。SS+GM组患者住院天数、住院费用均少于SS组,差异均有统计学意义(P <0.05)。两组患者药物不良反应发生率相近,差异无统计学意义(P> 0.05)。结论 SS联合GM对于HTG-AP患者的临床症状缓解、炎症指标恢复均优于单用SS,并可以缩短住院时间、减少住院费用,且不会增加药物不良反应发生率。
Objective To investigate the effect of somatostatin(SS)combined with gaberate mesylate(GM)in the treatment of hypertriglyceridemia acute pancreatitis(HTG-AP).Methods A total of 97 patients with HTG-AP admitted to our hospital from May 2019 to May 2023 were divided into SS group and SS+GM group,and the time of relief of abdominal distension,the time of relief of abdominal pain,the time of recovery of anal gas,the time of amylase return to normal,the length of hospital stay,hospitalization costs,and the incidence of adverse drug reactions were compared between the two groups,and the hypersensitive C-reactive protein(CRP),neutrophil-lymphocyte ratio(NLR)and white blood cell(WBC)were compared between the two groups before and after treatment.Results The time of relief of abdominal distension,the time of relief of abdominal pain,the time of recovery of anal gas and the time of amylase return to normal in the SS+GM group were shorter than those in the SS group,and the difference was statistically significant(P<0.05).After treatment,the levels of CRP,NLR and WBC in the two groups were lower than those before treatment,and the levels of SS+GM group were lower than those in the SS group,and the difference was statistically significant(P<0.05).The length of hospital stay and hospitalization cost of patients in the SS+GM group were significantly lower than those in the SS group(P<0.05).The incidence of adverse drug reactions was similar between the two groups,and the difference was not statistically significant(P>0.05).Conclusions SS combined with GM is better than SS alone for the alleviation of clinical symptoms and the recovery of inflammatory markers in patients with HTG-AP,and can shorten the length of hospitalization,reduce the cost of hospitalization,and will not increase the incidence of adverse drug reactions.
作者
张登月
ZHANG Dengyue(Suzhou Industrial Park Xinghu Hospital,Suzhou 215000,China)
出处
《中国医药指南》
2024年第3期56-58,共3页
Guide of China Medicine
