摘要
目的 探讨血清糖类抗原125(CA125)、糖类抗原19-9(CA19-9)、miRNA-17-5p水平与早期胃癌患者术后淋巴结转移的关系。方法 选取78例早期胃癌患者,均接受手术治疗,术后随访2年,依据随访期间是否发生淋巴结转移分为转移组和未转移组,比较两组患者的临床特征以及CA125、CA19-9和miRNA-17-5p水平。早期胃癌患者术后淋巴结转移的影响因素采用多因素Logistic回归分析。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评估CA125、CA19-9和miRNA-17-5p单独及联合检测对早期胃癌患者术后淋巴结转移的预测价值。结果 随访2年,78例早期胃癌患者术后淋巴结转移15例,未转移63例,分别作为转移组和未转移组。两组患者性别、年龄、体重指数(BMI)、饮酒史、吸烟史、合并糖尿病、合并高血压情况比较,差异均无统计学意义(P>0.05)。转移组患者血清CA125、CA19-9水平均明显高于未转移组,miRNA-17-5p水平明显低于未转移组,差异均有统计学意义(P<0.01)。多因素Logistic回归分析结果显示,CA125升高、CA19-9升高、miRNA-17-5p降低均为早期胃癌患者术后淋巴结转移的危险因素(P<0.05)。ROC曲线显示,CA125、CA19-9、miRNA-17-5p单独及联合检测预测早期胃癌患者术后淋巴结转移的AUC均> 0.7,且联合检测的AUC最大,为0.943 (95%CI:0.894-0.992)。结论 早期胃癌患者血清miRNA-17-5p水平降低与术后淋巴结转移密切相关,CA125升高、C A19-9升高、miRNA-17-5p降低均为早期胃癌患者术后淋巴结转移的危险因素。
Objective To investigate the correlation of serum carbohydrate antigen 125(CA125),carbohydrate antigen 19-9(CA19-9) and miRNA-17-5p with postoperative lymph node metastasis in early gastric cancer patients.Method A total of 78 patients with early gastric cancer were selected.All patients were treated with surgery and followed up 2years after surgery.According to occurrence of lymph node metastasis during follow-up,the patients were divided into metastatic group and non-metastatic group.The clinical characteristics,levels of CA125,CA19-9 and miRNA-17-5p of the two groups were compared.The influencing factors of postoperative lymph node metastasis in early gastric cancer patients were analyzed by multivariate Logistic regression.The receiver operating characteristic(ROC) curve was plotted,and the area under the curve(AUC) was calculated to evaluate the predictive value of CA125,CA19-9 and miRNA-17-5p individual and joint testing for postoperative lymph node metastasis in patients with early gastric cancer.Result There were 15 cases of postoperative lymph node metastasis and 63 cases of non-metastasis in 78 patients with early gastic cancer after 2 years follow up,who were divided into the metastasis group and the non-metastasis group,respectively.There were no statistical significant differences in gender,age,body mass index(BMI),drinking history,smoking history,diabetes and hypertension between the two groups(P>0.05).The level of serum CA125 and CA19-9 in the metastasis group were significantly higher than those in the non-metastasis group,and the level of miRNA-17-5p was significantly were lower than that in the non-metastasis group(P<0.05).The results of multivariate Logistic regression analysis showed that CA125 increased,CA19-9 increased,and miRNA-17-5p decreased were independent risk factors for postoperative lymph node metastasis in early gastric cancer patients(P<0.05).The ROC curve showed that the AUC of single and combined detection of CA125,CA19-9 and miRNA-17-5p in predicting postoperative lymph node me
作者
项志雄
邓辉球
郑美虹
何园芳
潘鋆
XIANG Zhixiong;DENG Huiqiu;ZHENG Meihong;HE Yuanfang;PAN Yun(Department of Gastroenterology,Shangrao People’s Hospital,Shangrao 334000,Jiangxi,China;Department of Internal Medicine,Shangrao Hospital of Traditional Chinese Medicine,Shangrao 334000,Jiangxi,China)
出处
《癌症进展》
2023年第22期2481-2484,2499,共5页
Oncology Progress
基金
江西省卫生健康委科技计划项目(202212722)。
关键词
早期胃癌
糖类抗原
淋巴结转移
影响因素
预测价值
early gastric cancer
carbohydrate antigen
lymph node metastasis
influencing factor
predictive value
