摘要
经皮给药系统具有患者依从性好、持续且受控给药、较高的局部浓度和避免新陈代谢等优势,是临床用药的有效途径之一。然而,因为人体皮肤具有多层屏障性质,大多数难溶性和大分子药物的透皮生物利用度较低,导致治疗效果不理想。近年来,离子液体(ionic liquids,ILs)的不断发展使这些药物透皮给药成为可能。ILs在室温下呈液态,是由阴离子和阳离子相互组成,但传统ILs的毒性和不稳定性限制了其应用。本文综述了皮肤结构、适用于经皮递送的ILs阴阳离子种类及其优缺点、药物经皮吸收的途径,及ILs促进药物透皮吸收的机制,分类介绍了影响ILs促进药物皮肤吸收的因素,最后对ILs促进药物透皮进行了展望。
Transdermal drug delivery system has the advantages of good patient compliance,continuous and controlled administration,high local concentration and avoidance of metabolism.Therefore,it is one of the effective ways of clinical medication.However,due to the multi-layer barrier properties of human skin,the transdermal bioavailability of most poorly soluble and macromolecular drugs is low,resulting in unsatisfactory therapeutic effects.In recent years,the continuous development of ionic liquids(ILs)has made it possible for these drugs to be transdermally administered.ILs are generally liquid at room temperature,which are composed of anions and cations,but the toxicity and instability of traditional ILs limit their application.This paper reviewed the skin structure,the types,the advantages and disadvantages of ILs anions and cations suitable for transdermal delivery,the ways of drug transdermal absorption,and the mechanism of promoting drug transdermal absorption by ILs.The factors affecting the promotion of drug transdermal absorption by ILs were introduced in categories.Finally,the prospect of promoting drug transdermal absorption by ILs was prospected.
作者
江紫荆
淦甜甜
孙勇兵
张琦
金一
奉建芳
涂亮星
JIANG Zijing;GAN Tiantian;SUN Yongbing;ZHANG Qi;JIN Yi;FENG Jianfang;TU Liangxing(National Engineering Research Center for Solid Preparation Technology of Chinese Medicine,Jiangxi University of Chinese Medicine,Nanchang 330006,China;College of Life Sciences,Jiangxi University of Chinese Medicine,Nanchang 330004,China;School of Pharmacy,Guangxi University of Chinese Medicine,Nanning 530200,China)
出处
《广东药科大学学报》
CAS
2024年第1期119-126,共8页
Journal of Guangdong Pharmaceutical University
基金
国家自然科学基金项目(81960717)
江西中医药大学校级科技创新团队发展计划(CXTD-22004)
江西省2022年度研究生创新专项(YC2022-s853)
国家级大学生创新创业训练计划项目(202110412009)
中央引导地方科技发展基金项目(20222ZDH04094)
江西省赣江新区重大科技攻关项目(2021007)。
关键词
离子液体
透皮递药系统
阴阳离子
ionic liquid
transdermal delivery
action and anion
