摘要
目的探讨既往服用阿司匹林与颅内动脉瘤破裂的关系。方法纳入2019年1月至2023年4月于南京市江宁医院神经内科住院的颅内动脉瘤患者177例。根据颅内动脉瘤是否破裂分为破裂组(59例)和非破裂组(118例);根据患者诊断为颅内动脉瘤时既往是否规律服用阿司匹林分为既往服药组(82例)和既往未服药组(95例)。收集患者一般临床资料和颅内动脉瘤资料。通过单变量分析及多因素Logistic回归分析探讨既往服用阿司匹林对颅内动脉瘤破裂的影响。结果破裂组患者高脂血症、既往服用他汀类药物和既往服用阿司匹林的比例与未破裂组比较差异有统计学意义(P<0.05)。采用多因素Logistic回归校正年龄、性别、高血压、吸烟、高脂血症、既往服用他汀类药物等因素后发现,既往服用阿司匹林是颅内动脉瘤破裂的保护因素(OR=0.235,95%CI:0.102~0.541,P=0.001)。既往服药组患者炎症因子(C反应蛋白、中性粒细胞与淋巴细胞比值)的水平、动脉瘤破裂比例均明显低于既往未服药组,差异有统计学意义(P<0.05)。既往服用阿司匹林>1年的患者发生颅内动脉瘤破裂的比例明显低于服用阿司匹林≤1年的患者(P<0.05)。结论既往服用阿司匹林与颅内动脉瘤破裂密切相关,是颅内动脉瘤破裂的保护因素,考虑与阿司匹林的抗炎作用有关,且这种保护因素在既往服用阿司匹林>1年的患者中更为显著。
Objective To investigate the association between the history of using aspirin and the occurrence of ruptured intracranial aneurysms.Methods A total of 177 patients with intracranial aneurysms who were hospitalized in Department of Neurology,Nanjing Jiangning Hospital,from January 2019 to April 2023 were enrolled.According to the presence or absence of ruptured intracranial aneurysms,the patients were divided into rupture group with 59 patients and non-rupture group with 118 patients;according to whether the patient took aspirin regularly before the diagnosis of intracranial aneurysms,they were divided into medication group with 82 patients and non-medication group with 95 patients.General clinical data and the data on intracranial aneurysms were collected,and the univariate analysis and the multivariate logistic regression analysis were used to investigate the impact of aspirin on the rupture of intracranial aneurysms.Results There were significant differences between the rupture group and the non-rupture group in the proportion of patients with hyperlipidemia or the history of using statins or aspirin(P<0.05).After adjustment for age,gender,hypertension,smoking,hyperlipidemia,and history of using statin,the multivariate logistic regression analysis showed that history of using aspirin was a protective factor against ruptured intracranial aneurysms(odds ratio=0.235,95% confidence interval:P=0.001).Compared with the non-medication group,the medication group had significantly lower levels of inflammatory factors(C-reactive protein and neutrophil-to-lymphocyte ratio)and a significantly lower proportion of patients with rupture of aneurysm(P<0.05).The patients who had taken aspirin for>1 year had a significantly lower proportion of patients with rupture of aneurysm than those who had taken it for≤1 year(P<0.05).Conclusions History of using aspirin is closely associated with the rupture of intracranial aneurysms and serves as a protective factor against such rupture,which is considered to be associated with the anti
作者
杨倩
李军荣
张雪梅
周淑宇
陈季南
YANG Qian;LI Junrong;ZHANG Xuemei;ZHOU Shuyu;CHEN Jinan(Department of Neurology,Nanjing Jiangning Hospital,Nanjing,Jiangsu 211100,China)
出处
《国际神经病学神经外科学杂志》
2023年第6期24-28,共5页
Journal of International Neurology and Neurosurgery
基金
南京医科大学科技发展基金(NMUB20220160)。
关键词
颅内动脉瘤破裂
阿司匹林
保护因素
ruptured intracranial aneurysms
aspirin
protective factor
