摘要
溃疡性结肠炎(UC)是一种病因复杂的慢性肠道炎症性疾病。该病发病机制复杂,至今尚未阐明,由多种因素共同促成。其中肠黏膜屏障损伤是UC的基本病理改变。自噬作为细胞的非损伤性应答,通过降解及重吸收等调节肠黏膜免疫、炎症、氧化应激及菌群稳态等多种过程,从而修复受损的肠黏膜屏障,在UC的发生发展中起关键作用。该病在临床上主要使用氨基水杨酸制剂、糖皮质激素及免疫抑制剂等治疗,西医治疗本病起效快,短期疗效确切,但长期使用容易伴随较多不良反应,且部分药品价格昂贵,给患者带来了极大的身心痛苦与经济负担。因此,探索疗效稳定、不良反应小的新疗法刻不容缓。近年来大量研究表明,中药能够多靶点、多效应调节肠黏膜细胞自噬,修复肠黏膜屏障功能,从而遏制UC发展。众多实验显示,中药活性成分或单体、复方可通过调节细胞自噬水平改善肠黏膜免疫、炎症、氧化应激及菌群等以维持肠黏膜屏障正常功能,从而有效干预UC,为防治UC提供了新举措。但目前尚缺乏对中药调节肠黏膜细胞自噬水平防治UC的系统综述。因此,该文基于UC研究现状、自噬过程、中药治疗等,综述了自噬及其关键靶点蛋白与UC的关系,以阐明自噬在UC产生中的关键作用。同时,对近年来靶向调节细胞自噬以治疗UC的中药进行系统总结,以期为UC的治疗及药物研发提供新思路。
Ulcerative colitis(UC)is a chronic inflammatory bowel disease with complex etiology.The pathogenesis of this disease,due to a combination of factors,is complex and has not yet been elucidated.Among them,intestinal mucosal barrier damage is the basic pathological change of UC.As a non-destructive response of cells,autophagy regulates intestinal mucosal immunity,inflammation,oxidative stress,and bacterial homeostasis through degradation and reabsorption to actively repair damaged intestinal mucosal barrier,exerting a key role in the occurrence and development of UC.The disease is mainly treated clinically with aminosalicylic acid preparations,glucocorticoids,and immunosuppressants.Western medicine treatment of the disease has a fast onset of effect,and the short-term efficacy is definite,but the long-term application is easy to be accompanied by more adverse reactions.Moreover,some drugs are expensive,bringing great physical and mental pain and economic burden to patients.Therefore,it is urgent to explore new therapies with stable efficacy and mild adverse effects.In recent years,a large number of studies have shown that Chinese medicine can regulate autophagy of the intestinal mucosa with multiple targets and effects and repair the intestinal mucosal barrier function,thereby inhibiting the development of UC.Many experiments have shown that the active ingredient or monomers and compound formulas of Chinese medicine can improve the immunity of the intestinal mucosa,inflammation,oxidative stress,and flora by regulating the level of autophagy to maintain the normal function of the intestinal mucosal barrier to effectively intervene in UC,providing a new measure for the prevention and treatment of UC.However,there is a lack of systematic review of Chinese medicine in regulating the level of autophagy in the intestinal mucosa for the prevention and treatment of UC.Therefore,based on the current research on UC,autophagy process,and Chinese medicine treatment,this article reviewed the relationship of autophagy and its key
作者
黄茂光
谢胜
王金鑫
罗峰
张云燕
陈月莹
蔡胜男
黄晓燕
黎丽群
HUANG Maoguang;XIE Sheng;WANG Jinxin;LUO Feng;ZHANG Yunyan;CHEN Yueying;CAI Shengnan;HUANG Xiaoyan;LI Liqun(Graduate School of Guangxi University of Chinese Medicine,Nanning 530001,China;The First Affiliated Hospital of Guangxi University of Chinese Medicine,Nanning 530001,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2024年第4期281-289,共9页
Chinese Journal of Experimental Traditional Medical Formulae
基金
广西岐黄学者培养项目(2022015-003-01)
广西自然科学基金项目(2020GXNSFAA238009)
广西中医药大学桂派中医药传承创新团队项目(2021B001)
广西中医药大学研究生院创新课题(YCSY2022026)。
关键词
自噬
溃疡性结肠炎
作用机制
中药
autophagy
ulcerative colitis
mechanism of action
Chinese medicine
