摘要
目的分析胸段食管癌放疗时双肺剂量学参数与计划参数的相关性。方法选取2020年4月至2023年4月医院收治的99例胸段食管癌放疗患者,采集放射性肺炎相关的剂量学参数如双肺V_(5)、V_(10)、V_(20)、V_(30)和平均剂量(Dmean)等,选取计划参数如处方剂量(DP)、双肺体积(VBL)、靶区体积(VPTV)和靶区与肺重合体积(VOPL)等,分析胸段食管癌放疗中双肺剂量学参数与计划参数的相关性。结果当双肺剂量学参数组合为第1典型变量(V1)、计划参数组合为第1典型变量(U_(1))时,两组典型变量的相关系数ρ=0.848,差异有统计学意义(P<0.05),其他组合的相关系数比较,差异无统计学意义(P>0.05)。其中V_(1)包括双肺剂量学参数中的V_(5)、V_(20)、V_(30)和Dmean,U_(1)包括计划参数中的处方剂量(DP)、双肺体积(VBL)和靶区体积(VPTV)。结论V_(5)、V_(20)、V_(30)和Dmean均是重要的双肺剂量学参数,其中,物理师需密切关注Dmean。计划参数的影响因素包括DP、VBL和VPTV,其中VPTV是影响双肺剂量学参数的重要因素。
Objective To analyze the correlation between bilateral lung dosimetric parameters and planning parameters during radiotherapy for thorax.Methods A total of 99 cases of thoracic esophageal cancer radiotherapy in hospital were selected from April 2020 to April 2023,and the dosimetric parameters related to radiation pneumonitis such as bilateral lung V_(5),V_(10),V_(20),V_(30),and mean dose(Dmean)were collected,and the planning parameters such as dose of prescription(DP),volume of bilateral lung(VBL),volume of planning target volume(VPTV),and volume of overlap between PTV and lung(VOPL)were selected,and analyzed the correlation between bilateral lung dosimetric parameters and planning parameters in radiotherapy for thoracic esophageal cancer.Results The correlation coefficientρ=0.848 of the two canonical variables was statistically significant(P<0.05)when the combination of bilateral lung dosimetric parameters was the 1st canonical variable(V_(1))and the combination of planning parameters was the 1st canonical variable(U1),and the correlation coefficients of the other combinations were not statistically significant(P>0.05).Where V_(1) included V_(5),V_(20),V_(30),and Dmean in the bilateral lung dosimetric parameters,U1 included dose of prescription(DP),volume of bilateral lung(VBL),and volume of planning target volume(VPTV)in the planning parameters.Conclusions V_(5),V_(20),V_(30),and Dmean were important bilateral lung dosimetric parameters in the thoracic esophageal cancer radiotherapy,where Dmean needs to be closely examined by physicists.The influencing factors in the planning parameters included DP,VBL,and VPTV,with VPTV being the most prominent factor,among them,the VPTV is an important factor influencing the dosimetric parameters in bilateral lung.
作者
田玉龙
黄洋洋
Tian Yulong;Huang Yangyang(The Fifth Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450052,China;The Second Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450014,China)
出处
《医疗装备》
2024年第1期18-21,共4页
Medical Equipment
基金
河南省医学科技攻关计划项目(LHGJ20210407)。
关键词
胸段食管癌
放射治疗
双肺剂量学参数
计划参数
Thoracic esophageal cancer
Radiotherapy
Bilateral lung dosimetric parameters
Plan parameters
