摘要
目的分析替格瑞洛配合急诊PCI治疗急性心肌梗死(acute myocardial infarction,AMI)的效果。方法选取2019年5月至2021年6月河南省人民医院急诊内科收治的AMI患者84例,均予以急诊PCI治疗,随机分为研究组和对照组各42例,对照组应用氯吡格雷治疗,研究组应用替格瑞洛治疗,比较两组效果。结果研究组总有效率95.24%,高于对照组的73.81%(P<0.05);治疗前两组肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、白介素-6(interleukin-6,IL-6)、血清超敏C反应蛋白(hypersensitive C-reactive protein,hs-CRP)水平比较差异无统计学意义(P>0.05),治疗后IL-6、TNF-α和hs-CRP水平均降低,且研究组IL-6、TNF-α和hs-CRP水平分别为(0.79±0.23)μg/L、(18.76±3.29)ng/L和(3.28±0.75)μg/L,均低于对照组(P<0.05);治疗前两组左室舒张末期内径(LVEDD)、左室收缩末期内径(LVESD)以及左室射血分数(LVEF)等心功能指标比较无统计学意义(P>0.05),研究组治疗后的LVEDD(53.45±3.87)mm、LVESD(36.18±3.62)mm,均低于对照组,LVEF(48.59±4.05)高于对照组(P<0.05);治疗前两组丙二醛(MDA)、谷胱甘肽过氧化物酶(GPX)、超氧化物歧化酶(SOD)等氧化应激指标比较差异无统计学意义(P>0.05),研究组治疗后MDA(4.05±0.67)mmol/mL,低于对照组,GSH-Px和SOD为(254.76±39.83)IU/L、(73.75±9.42)IU/mL,均高于对照组(P<0.05);研究组中发生不良事件2例,分别为心动过缓和出血,总发生率为4.76%,低于对照组的19.04%(P<0.05)。结论替格瑞洛配合急诊PCI治疗能够显著增强疗效,缓解患者炎性反应及并降低氧化应激水平,促进患者心功能恢复,且安全性良好。
Objective To analyze the effect of ticagrelor combined with emergency PCI in the treatment of acute myocardial infarction(AMI).Methods A total of 84 patients with acute myocardial infarction in our hospital from May 2019 to June 2021 divided into selected the study group and the control group by random number table method,42 patients in each group.Both groups were treated with emergency PCI.On this basis,the control group treated with clopidogrel,study group treated with ticagrereol.Results The total effective rate of the study group was 95.24%,which was higher than that of the control group(73.81%,P<0.05).Tumor necrosis factor-α(TNF-α),Interleukin-6(IL-6),serum Hypersensitive C-reactive protein,and necrosis necrosis factor-α(TNF-α)in the first two groups were treated.There was no significant difference in hs-CRP levels(P>0.05).IL-6,TNF-αand hs-CRP levels were all decreased after treatment.The levels of IL-6,TNF-αand hs-CRP in the study group were(0.79±0.23)μg/L,(18.76±3.29)ng/L and(3.28±0.75)μg/L,respectively,which were lower than those in the control group(P<0.05).Two groups before treatment of left ventricular end-diastolic diameter(LVEDD),left ventricular end systolic diameter(LVESD)and left ventricular ejection fraction(LVEF)and cardiac function indexes was no statistical significance(P>0.05),the study group after treatment of LVEDD(53.45±3.87)mm,LVESD(36.18±3.62)mm,The LVEF(48.59±4.05)were higher than those of the control group(P<0.05).The oxidative stress indexes such as malondialdehyde(MDA),glutathione peroxidase(GPX)and superoxide dismutase(SOD)were compared between the two groups before treatment has no statistical difference(P>0.05).The MDA of the study group after treatment was(4.05±0.67)mmol/mL,which was lower than that of the control group.GSH-Px and SOD were(254.76±39.83)IU/L and(73.75±9.42)IU/mL,which were higher than those in control group(P<0.05).Two adverse events occurred in the study group,bradycardia and hemorrhage,respectively,with a total incidence of 4.76%,which was lower
作者
胡梦冰
常玉霞
姜鹏丽
HU Meng-bing;CHANG Yu-xia;JIANG Peng-li(Department of Emergency,Henan Provincial Peoples Hospital,Henan Provincial Key Laboratory of Nursing Medicine,Peoples Hospital of Zhengzhou University,Zhengzhou 450003,China)
出处
《医药论坛杂志》
2023年第22期88-92,共5页
Journal of Medical Forum
关键词
急性心肌梗死
替格瑞洛
氧化应激
急诊PCI
安全性
心功能
Acute myocardial infarction
For Grillo
Oxidative stress
Emergency PCI
Security
Cardiac function
