摘要
本研究首先对生血宝合剂药渣(SXBR)从营养物质和药用活性成分两方面进行成分表征,然后将0%(SXBRc组)、5%(SXBRl组)、10%(SXBRm组)和20%(SXBRh组)比例的SXBR添加到新西兰兔的基础饲粮中,对新西兰兔的生产性能、抗氧化应激功能、骨髓造血功能和肠道菌群进行考察,并表征其潜在毒性。研究结果表明:SXBR含有丰富的碳水化合物、粗脂肪等营养物质,且含有大量三萜类和黄酮类等活性成分。相比SXBRc组,SXBRh组在第44、54、57天的体重增量增加了60%以上,60 d料重比降低了43.85%,且SXBR各添加组屠宰率均增加了6%以上。以上结果差异均具有统计学意义(P<0.05),表明SXBR生产性能良好。SXBRh组血清超氧化物歧化酶(SOD)活性相比SXBRc组显著增强了91.70%(P=0.003),丙二醛(MDA)含量显著降低了80.62%(P=0.010)。此外,SXBR可抑制骨髓细胞凋亡,改善肠道菌群结构,具有良好的安全性。可见,SXBR是生产食草动物饲料的良好原料,也可开发为抗氧化应激、调节肠道微生态、促生长的饲料添加剂。本研究对实现SXBR饲料化应用,促进中药渣循环利用具有现实意义。
In this study,the ingredients of Shengxuebao mixture drug residue(SXBR)were characterized from two aspects:nutrients and pharmaceutical active ingredients.Then New Zealand rabbits were divided into four groups randomly.Then added 0%(SXBRc),5%(SXBRl),10%(SXBRm),and 20%(SXBRh)of SXBR to the basic diet of New Zealand rabbits to investigate the production performance,antioxidant stress function,bone marrow hematopoietic function and intestinal flora of New Zealand rabbits,and characterize its potential toxicity.The results showed that SXBR was rich in carbohydrate,crude fat and other nutrients,and contained a large number of triterpenoids,flavonoids and other active ingredients.Compared with the SXBRc,the body weight gain of the SXBRh was increased by more than 60%on the 44th,54th and 57th days,and the feed conversion ratio was decreased by 43.85%within 60 days.Moreover,the slaughter rate of each SXBR addition group was increased by more than 6%compared to the SXBRc.The differences in the above results were statistically significant(P<0.05),indicating good production performance of SXBR.The serum superoxide dismutase(SOD)activity of the SXBRh was significantly increased by 91.70%(P=0.003)compared to the SXBRc,and the malondialdehyde(MDA)content was significantly reduced by 80.62%(P=0.010).In addition,SXBR could inhibit bone marrow cell apoptosis,improve the structure of intestinal microbiota,and had good safety.It could be seen that the SXBR was a good raw material for the production of forage for herbivores and could also be developed as a feed additive for anti-oxidative stress,regulating intestinal microecology and promoting growth.This study had practical significance for realizing the feed application of SXBR and promoting the recycling of traditional Chinese medicine residue.
作者
贺宇
于金高
宋忠兴
唐志书
段金廒
朱华旭
刘红娜
周建平
曹兆军
HE Yu;YU Jingao;SONG Zhongxing;TANG Zhishu;DUAN Jinao;ZHU Huaxu;LIU Hongna;ZHOU Jianping;CAO Zhaojun(Co-construction Collaborative Innovation Center for Chinese Medicine Resources Industrialization by Shaanxi&Education Ministry,State Key Laboratory of Research&Development of Characteristic Qin Medicine Resources(Cultivation),Shaanxi University of Chinese Medicine,Xianyang,Shaanxi Province 712046,China;China Academy of Chinese Medical Sciences,Beijing 100700,China;Nanjing University of Chinese Medicine,Jiangsu Provincial Engineering Research Center for Deep Processing of Plant Medicines,Jiangsu Province Collaborative Innovation Center for Industrialization of Traditional Chinese Medicine Resources,Nanjing,Jiangsu Province 210023,China;Tsing Hua De Ren Xi'an Happiness Pharmaceutical Co.,Ltd.,Xi'an,Shaanxi Province 710043,China)
出处
《中国饲料》
北大核心
2024年第3期59-68,共10页
China Feed
基金
中央本级重大增减支项目“名贵中药资源可持续利用能力建设项目”(2060302)
中药大品种品牌价值提升示范研究(202190025)。
关键词
药渣
循环利用
饲料
氧化应激
微生态
medicine residue
recycling
feed
oxidative stress
microecology
