摘要
巨噬细胞是固有免疫系统的主要组成部分,由血液中单核细胞分化而来,帮助宿主抵御炎症和肿瘤。大部分的肿瘤可将巨噬细胞驯化为肿瘤相关巨噬细胞(TAM),促进肿瘤的生长、侵袭和转移,并对化疗和免疫检查点抑制剂产生耐药性。然而,巨噬细胞经适当的激活时也可以通过增强对肿瘤细胞的吞噬作用和细胞毒性来发挥抗肿瘤作用。此外,TAM与肿瘤治疗包括免疫治疗的不良预后和耐药相关,这表明巨噬细胞是肿瘤治疗中联合治疗的诱人靶点。在此,我们将对巨噬细胞在肿瘤发生、转移和免疫治疗中的作用进行综述。基于以巨噬细胞为中心包括消耗和重塑TAM的治疗策略来描述肿瘤免疫治疗的潜在靶点。
Macrophages are the main components of the innate immunity system,derived mainly from blood monocytes,and help the host to defend itself against many pathogens and cancers.Most established tumors can educate macrophages into tumor-associated macrophages(TAMs),which contribute to tumor growth,invasion and metastasis,as well as resistance to chemotherapeutic agents and immune checkpoint inhibitors.However,when appropriately activated,macrophages can also exert anti-tumor effects through enhanced phagocytosis and cytotoxicity against tumor cells.In addition,TAMs are associated with poor prognosis and drug resistance,including immunotherapies,suggesting that macrophages are attractive targets as part of combination therapy in cancer treatment.Herein,we review the recent findings on the role of macrophages in tumor development,metastasis and immunotherapy.We focus mainly on macrophage-centered therapy,including strategies to reduce and reshape TAMs,to represent potential targets for tumor immunotherapy.
作者
胡果荣
尹雯
韩杰丽
肖阳
胡轶
Hu Guorong;Yin Wen;Han Jieli;Xiao Yang;Hu Yi(Department of Respiratory and Critical Care Medicine,The Central Hospital of Wuhan,Tongji Medical College,Huazhong University of Science and Technology,Wuhan Clinical Research Center for Interventional Diagnosis and Treatment of Respiratory Diseases,Wuhan 430014,China)
出处
《中华结核和呼吸杂志》
CAS
CSCD
北大核心
2024年第1期75-81,共7页
Chinese Journal of Tuberculosis and Respiratory Diseases
基金
湖北省自然科学基金(2022CFB729)
武汉市卫生健康委医学科研项目(WX21Q04,WX18Q25)。
