摘要
目的探讨中文版电休克治疗认知评估(electroconvulsive therapy cognitive assessment,ECCA)量表在成年早期抑郁症患者中的心理测量特征。方法本研究于2021年1月至2022年12月在首都医科大学附属北京安定医院进行。最终共纳入成年早期抑郁症患者40例,健康对照组30例。对接受电休克治疗(electroconvulsive therapy,ECT)的成年早期抑郁症患者在3个时间点进行ECCA和蒙特利尔认知评估(Montreal cognitive assessment,MoCA),即治疗前(基线)、第5次治疗后和治疗结束后5~10 d。健康受试者进行1次ECCA评估。统计学分析采用χ^(2)检验、重复测量方差分析、t检验、Pearson相关性分析。结果成年早期抑郁症组与对照组的年龄、性别、受教育年限比较,差异均无统计学意义(P值均>0.05)。但成年早期抑郁症组的ECCA基线评分低于对照组[(27.75±1.77)与(29.10±0.80)分,t=-3.687,P<0.001];MoCA基线评分低于对照组[(27.39±0.23)与(29.60±0.30)分,t=-11.640,P<0.001]。ECCA内部一致性分析中的Cronbach'α系数为0.811(P<0.001)。ECCA评分ECT前[(27.75±1.77)分]>ECT中[(25.17±1.73)分]>ECT后[(21.90±3.67)分](F=13.242,P值均<0.001),而MoCA评分在这3个时间点比较,差异无统计学意义(F=1.871,P=0.171)。在排除性别、年龄、教育水平的影响因素后,ECCA总分与基线时成年早期抑郁症患者的MoCA评分(r=0.450,P<0.01)和汉密尔顿抑郁量表(Hamilton depression scale-17 item,HDRS-17)评分(r=-0.621,P<0.01)有关。结论中文版ECCA具有较好的心理测量特性,可作为成年早期抑郁症患者中评估ECT相关认知损害的临床应用工具。
Objective To explore the psychometric characteristics of the Chinese version of the electroconvulsive therapy cognitive assessment(ECCA)in early adult patients with depression.Method The study was conducted at Beijing Anding Hospital,Capital Medical University from January 2021 to December 2022.Finally,a total of 40 early adults with depression and 30 healthy controls were included.ECCA and the Montreal cognitive assessment(MoCA)were performed at three time points in early adults with depression who were treated with electroconvulsive therapy(ECT).That is,before treatment(baseline),after the fifth treatment,and 7-10 days after the end of treatment.Healthy subjects underwent an ECCA assessment.Statistical analysis performed byχ^(2) test,repeated measurements of ANOVA,t-test,Pearson correlation analysis.Result There were no significant differences in age,gender and years of education between the depression group and the control group(all P>0.05).However,the baseline ECCA score in the arly adult depression group was lower than that in the control group[(27.75±1.77)vs(29.10±0.80)points,t=-3.687,P<0.001].The baseline MoCA score was lower than that of the control group[(27.39±0.23)vs(29.60±0.30)points,t=-11.640,P<0.001].Cronbach'αin ECCA internal consistency analysis was 0.811(P<0.001).ECCA scores before ECT[(27.75±1.77)points]>during ECT[(25.17±1.73)points]>after ECT[(21.90±3.67)points](F=13.242,all P<0.001),while MoCA scores at these three time points showed no significant difference(F=1.871,P=0.171).After controlling for gender,age,and education level,the total ECCA score was highly correlated with MoCA(r=0.450,P<0.01)and Hamilton depression scale-17 item(HDRS-17)(r=-0.621,P<0.01)at baseline in early adult patients with depression.Conclusion The Chinese version of ECCA has good psychometric characteristics and can be used as a clinical tool to assess ECT related cognitive impairment in early adult patients with depression.
作者
于红晔
刘君
沙莎
Yu Hongye;Liu Jun;Sha Sha(Ward 5,Depression Treatment Center,Beijing Anding Hospital,Capital Medical University,Beijing 100088,China)
出处
《发育医学电子杂志》
2024年第1期47-52,共6页
Journal of Developmental Medicine (Electronic Version)
关键词
电休克治疗
成年早期
抑郁症
认知损害
Electroconvulsive therapy
Early adulthood
Depression
Cognitive impairment
