摘要
目的 探讨高压氧联合血管内治疗急性脑梗死(ACI)的疗效。方法 选取解放军海军青岛特勒疗养中心2020年1月~2021年12月收治的ACI患者134例,随机数表法分为观察组和对照组,各67例。对照组实施血管介入取栓术治疗,观察组实施高压氧联合血管介入治疗。对比两组临床疗效、治疗前后脑血流灌注[脑血流量(CBF)、脑血容量(CBV)]、血氧饱和度(SaO2)、血清白细胞介素-1β(IL-1β)、IL-6以及单核细胞趋化蛋白-1(MCP-1)水平。结果 观察组总有效率为91.04%(61/67)高于对照组77.61%(52/67),差异有统计学意义(P<0.05)。治疗后,观察组NIHSS评分低于对照组[(5.85±1.46)分vs.(9.28±2.04)分],差异有统计学意义(t=10.573,P<0.05);随访3个月时,观察组改良Rankin量表(mRS)评分优于对照组,差异有统计学意义(χ2=4.772,P<0.05)。观察组CBF、CBV及SaO2大于对照组[(22.86±2.49)ml/(100 g·min)vs.(19.35±2.12)ml/(100 g·min)、(2.28±0.31)ml/100 g vs.(1.96±0.29)ml/100 g、(91.65±9.25)%vs.(84.26±6.96)%],差异有统计学意义(t=7.797、7.776、4.669,P<0.05);观察组血清IL-1β、IL-6及MCP-1水平低于对照组[(5.31±1.26)ng/L vs.(6.08±1.38)ng/L、(22.89±4.51)ng/L vs.(28.63±5.04)ng/L、(137.58±27.52)μg/L vs.(161.87±28.76)μg/L],差异有统计学意义(t=3.535、7.539、4.963,P<0.05)。结论 高压氧联合血管介入治疗能够改善脑血流灌注,抑制炎症反应,从而提高ACI患者预后。
Objective To investigate the effect of hyperbaric oxygen combined with endovascular treatment on acute cerebral infarction(ACI).Methods A total of 134 patients with ACI in our hospital from January 2020 to December 2021 were randomly divided into an observation group and a control group,67 cases for each group.The control group was treated with vascular interventional thrombectomy,and the observation group was treated with hyperbaric oxygen combined with vascular interventional therapy.The clinical efficacy,cerebral blood flow perfusion[cerebral blood flow(CBF),cerebral blood volume(CBV)],blood oxygen saturation(SaO 2),serum interleukin-1β(IL-1β),interleukin-6(IL-6)and monocyte chemoattractant protein-1(MCP-1)levels before and after treatment were compared between the two groups.Results The total effective rate of the observation group was 91.04%(6167),which was higher than 77.61%(5267)of the control group(P<0.05).After treatment,the NIHSS score of the observation group was lower than that of the control group(P<0.05),and the mRS score of the observation group was better than that of the control group at 3 months of follow-up(P<0.05).The CBF,CBV and SaO 2 in the observation group after treatment were higher than those in the control group(P<0.05),and the serum levels of IL-1β,IL-6 and MCP-1 in the observation group after treatment were lower than those in the control group(P<0.05).The total effective rate of the observation group was 91.04%(6167),which was higher than 77.61%(5267)of the control group(P<0.05).After treatment,the NIHSS score of the observation group was lower than that of the control group[(5.85±1.46)points vs.(9.28±2.04)points](t=10.573,P<0.05),and the mRS score of the observation group was better than that of the control group at 3 months of follow-up(χ2=4.772,P<0.05).The CBF,CBV and SaO 2 in the observation group after treatment were higher than those in the control group[(22.86±2.49)ml(100 g·min)vs.(19.35±2.12)ml(100 g·min),(2.28±0.31)ml 100 g vs.(1.96±0.29)ml 100 g,(91.65±9.25)%vs
作者
刘林
刘欣
窦京彬
张云霞
Liu Lin;Liu Xin;Dou Jingbin(Fifth District Clinic,the People′s Liberation Army Navy Qingdao Special Service Recuperation Center,Qingdao 266071,China)
出处
《中华保健医学杂志》
2023年第5期504-507,共4页
Chinese Journal of Health Care and Medicine
基金
山东省中医药科技项目(2020MS111)。
关键词
急性脑梗死
高压氧
血管内介入治疗
脑血流灌注
炎症反应
Acute cerebral infarction
Hyperbaric oxygen
Endovascular interventional therapy
Cerebral blood flow perfusion
Inflammatory response
