摘要
目的:比较术前选择性双侧髂内动脉介入灌注化疗并栓塞与全身静脉化疗对晚期子宫颈癌患者的治疗效果和预后评价。方法:选取2018年10月—2020年12月于中国人民解放军联勤保障部队第九六〇医院妇科收治的65例晚期子宫颈癌患者为研究目标,按术前新辅助化疗(neoadjuvant chemotherapy,NACT)方式不同分为A组(术前选择性双侧髂内动脉介入灌注化疗并栓塞及子宫颈癌根治术)33例和B组(全身静脉化疗及子宫颈癌根治术)32例,两组互为对照。比较两组患者的总有效率、肿瘤大小变化的差异、血清鳞状细胞癌抗原(squamous cell carcinoma antigen,SCCA)水平的差异、术后随访恶性肿瘤复发情况的差异。结果:两组经过化疗后总有效率差异无统计学意义(P>0.05)。两组化疗前肿瘤最大径及SCCA比较,差异均无统计学意义(P>0.05);化疗后,A组肿瘤最大径及SCCA均优于B组,差异均有统计学意义(P<0.05);术后1周,B组SCCA低于A组,差异有统计学意义(P<0.05)。两组复发率差异无统计学意义(P>0.05)。结论:术前选择性双侧髂内动脉介入灌注化疗并栓塞治疗与全身静脉化疗对晚期子宫颈癌疗效均表现较好,选择性双侧髂内动脉介入灌注化疗并栓塞治疗虽略好于全身静脉化疗,无显著差异;前者对缩小肿瘤组织的疗效更为显著,能更有效降低SCCA,术后复发率也较后者低。
Objective:To compare the therapeutic effect and prognostic evaluation of preoperative selective bilateral iliac artery infusion chemotherapy and embolization with systemic intravenous chemotherapy in patients with advanced cervical cancer.Method:A total of 65 patients with advanced cervical cancer admitted to the Gynecology Department of the 960th Hospital of the Chinese People's Liberation Army Joint Logistics Support Force from October 2018 to December 2020 were selected as the research objectives,according to different preoperative neoadjuvant chemotherapy(NACT)methods,33 cases were divided into group A(preoperative selective bilateral iliac artery infusion chemotherapy with embolization and cervical cancer radical surgery)and 32 cases in group B(systemic intravenous chemotherapy and cervical cancer radical surgery),the two groups were contrasted with each other.The total effective rate,tumor size change,serum squamous cell carcinoma antigen(SCCA)level and postoperative follow-up of malignant tumor recurrence were compared between the two groups.Result:There was no significant difference in total response rate between the two groups after chemotherapy(P>0.05).There were no significant differences in maximum tumor diameter and SCCA between the two groups before chemotherapy(P>0.05);after chemotherapy,the maximum tumor diameter and SCCA in group A were better than those in group B,the differences were statistically significant(P<0.05);1 week after surgery,SCCA in group B was lower than that in group A,the difference was statistically significant(P<0.05).There was no significant difference in recurrence rate between the two groups(P>0.05).Conclusion:Both preoperative selective bilateral iliac artery infusion chemotherapy and embolization therapy and systemic venous chemotherapy have shown good therapeutic effects on cervical malignant tumors.However,selective bilateral iliac artery infusion chemotherapy and embolization therapy are slightly better than systemic venous chemotherapy,no statistically significant dif
作者
葛坤
尹格平
段升艳
GE Kun;YIN Geping;DUAN Shengyan(Jinzhou Medical University,Jinzhou 121000,China;不详)
出处
《中国医学创新》
CAS
2024年第2期27-31,共5页
Medical Innovation of China
关键词
晚期子宫颈癌
动脉介入化疗并栓塞
全身静脉化疗
子宫颈癌根治术
Advanced cervical cancer
Arterial interventional chemotherapy and embolization
Systemic intravenous chemotherapy
Radical resection of cervical cancer
