摘要
目的研究黄芪注射液对高钾血症家兔的影响,并初步探讨黄芪注射液对高钾血症家兔是否具有保护作用。方法将家兔随机分为生理盐水组、葡萄糖酸钙组和黄芪注射液组,分别用药物做预处理,注射氯化钾造高钾血症模型,观察三组家兔心率、心电图的变化,并记录氯化钾的消耗量。结果预处理前,家兔心率较稳定,心电图无明显异常波形。预处理10 min后,三组家兔较预处理前出现基线不稳,生理盐水组和黄芪注射液组心率加快,葡萄糖酸钙组心率减慢;预处理20 min后,三组家兔心率均减慢,生理盐水组出现了室性颤动(正弦波),黄芪注射液组和葡萄糖酸钙组均出现QRS波增宽和高尖的T波,且黄芪注射液组更明显。三组心率、氯化钾的消耗量比较,差异有统计学意义(P<0.05)。结论黄芪注射液对高钾血症诱发的家兔心律失常具有一定的保护作用,且保护作用接近葡萄糖酸钙,这为临床预防高钾血症开拓了新的思路。
Objective To study the effect of Huangqi injection on hyperkalemia rabbits,and preliminarily explore whether Huangqi injection has protective effect on hyperkalemia rabbits.Methods Rabbits were randomly divided into normal saline group,calcium gluconate group and Huangqi injection group.Hyperkalemia model was established by drug pretreatment and potassium chloride injection,respectively.The rabbits were pretreated with drugs and injected with potassium chloride to establish hyperkalemia model.The changes of heart rate and electrocardiogram of the three groups were observed,and the consumption of potassium chloride was recorded.Results Before pretreatment,the heart rate of rabbits was stable,and there was no obvious abnormal waveform in electrocardiogram.After 10 min of pretreatment,the three groups of rabbits showed baseline instability compared with that before pretreatment,the heart rate of the saline group and the Huangqi injection group was accelerated,and the heart rate of the calcium gluconate group was slowed down.After 20 min of pretreatment,the heart rate of rabbits in the three groups slowed down,ventricular fibrillation(sine wave)appeared in the saline group,QRS wave broadening and high T wave appeared in the Huangqi injection group and calcium gluconate group,and the Huangqi injection group was more obvious.There were significant differences in heart rate and potassium chloride consumption among the three groups(P<0.05).Conclusion Huangqi injection has a certain protective effect on rabbit arrhythmia induced by hyperkalemia,and the protective effect is close to calcium gluconate.This has opened up a new way for clinical prevention of hyperkalemia.
作者
张娟娟
王锦
张子境
杜玉莎
王丽娜
张佳丽
王云
ZHANG Juan-juan;WANG Jin;ZHANG Zi-jing;DU Yu-sha;WANG Li-na;ZHANG Jia-li;WANG Yun(Medical College of Hexi University,Zhangye 734000,Gansu,China)
出处
《医学信息》
2024年第2期111-114,119,共5页
Journal of Medical Information
基金
2021年甘肃省高等学校创新基金项目(编号:2021A-119)
2022年甘肃省高等学校创新基金项目(编号:2022B-179)
河西学院第十二批科技创新项目(编号:107)。
关键词
黄芪注射液
高钾血症
室颤
保护作用
Huangqi injection
Hyperkalemia
Ventricular fibrillation
Protective effect
