摘要
目的:探讨在ICU中氧气驱动下口含式与面罩式雾化吸入治疗,对于慢性阻塞性肺病急性加重期的治疗效果对比。方法:选取2021年5月—2022年5月中国人民解放军南部战区总医院收治的慢性阻塞性肺疾病急性加重期患者80例为研究对象,采用随机法分为口含式组与面罩式组,各40例。比较两组临床疗效、肺功能指标、动脉血气指标、问卷调查及不良反应发生情况。结果:口含式组临床疗效总有效率高于面罩式组,差异有统计学意义(P=0.043);治疗后,口含式组用力肺活量(FVC)、第1 s用力呼气量(FEV_(1))、FEV_(1)/FVC水平高于面罩式组,差异有统计学意义(P<0.05);治疗后,口含式组动脉氧分压水平低于面罩式组,二氧化碳分压、血氧饱和度水平高于面罩式组,差异有统计学意义(P<0.05);治疗后,口含式组呼吸困难量表、慢阻肺疾病评估量表、睡眠呼吸暂停临床及Epworth嗜睡量表评分低于面罩式组,差异有统计学意义(P<0.05);口含式组不良反应发生率低于面罩式组,差异有统计学意义(P=0.046)。结论:在ICU中采用氧气驱动口含式雾化吸入治疗慢性阻塞性肺疾病急性加重期较氧气驱动面罩式雾化吸入治疗效果更优,可优化肺功能指标、动脉血气指标,缓解疾病相关症状,不良反应小。
Objective:To investigate the comparison of therapeutic effects of oxygen-driven oral and mask nebulized inhalation therapy for acute exacerbation of chronic obstructive pulmonary disease(COPD)in ICU.Methods:Eighty patients with acute exac⁃erbation of chronic obstructive pulmonary disease admitted to Chinese People's Liberation Army Southern Theater Command Gen⁃eral Hospital from May 2021 to May 2022 were selected as the study subjects,and were divided into the oral group and the mask group using the randomization method,with forty cases in each group.The clinical efficacy,pulmonary function indexes,arterial blood gas indexes,questionnaires and the occurrence of adverse reactions were compared between the two groups.Results:The to⁃tal effective rate of clinical efficacy of the oral group was higher than that of the mask group,and the difference was statistically significant(P=0.043);After treatment,the levels of forceful lung volume(FVC),forceful expiratory volume in the 1st s(FEV_(1)),and FEV_(1)/FVC in the oral group were higher than those in the masked group,and the difference was statistically significant(P<0.05);After treatment,the level of arterial partial pressure of oxygen in the oral group was lower than that in the mask group,and the lev⁃els of partial pressure of carbon dioxide and oxygen saturation were higher than those in the mask group,and the difference was statistically significant(P<0.05);After treatment,the scores of dyspnea scale,chronic obstructive pulmonary disease assessment scale,sleep apnea clinical and Epworth drowsiness scale were lower in the oral group than in the mask group,and the difference was statistically significant(P<0.05);The incidence of adverse reactions in the oral group was lower than that in the mask group,and the difference was statistically significant(P=0.046).Conclusion:The use of oxygen-driven oral nebulized inhalation for acute exacerbation of chronic obstructive pulmonary disease in ICU is more effective than oxygen-driven mask nebulized inhalation,which ca
作者
张金峰
肖盛华
施学智
Zhang Jinfeng;Xiao Shenghua;Shi Xuezhi(Department of Critical Care Medicine,Chinese People's Liberation Army Southern Theater Command General Hospital,Guangzhou 510010,Guangdong Province,China)
出处
《中外医药研究》
2023年第26期84-86,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
慢性阻塞性肺疾病
口含式雾化
面罩式雾化
肺功能
血气分析
Chronic obstructive pulmonary disease
Oral nebulization
Mask nebulization
Lung function
Blood gas analysis
