摘要
目的:探究不同成分输血比例在创伤大出血患者住院输血治疗中的影响。方法:选取2021年3月—2022年3月甘孜藏族自治州人民医院急诊科收治的大出血患者96例为研究对象,按照其输血成分的不同分为对照组、观察1组与观察2组,各32例。随机分为三组,对照组、观察1组、观察2组冰冻血浆(FP)与悬浮红细胞(RBC)血制品成分比例分别为≤1:2、>1:2~1:1、>1:1,比较三组患者输血治疗中FP与悬浮RBC输注量,输血前后患者凝血功能指标[凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、国际标准化比值(INR)]变化。结果:三组患者住院期间FP输注量呈现依次递增趋势,差异有统计学意义(P<0.05);三组患者悬浮RBC输注量比较,差异无统计学意义(P>0.05)。输血前,三组患者PT、APTT、INR比较,差异无统计学意义(P>0.05);输血后,观察1组PT、APTT、INR均低于对照组和观察2组,差异有统计学意义(P<0.05)。结论:对于创伤性大出血患者,可给予FP:悬浮RBC>1:2~1:1成分输血,能有效改善患者的凝血功能障碍,在保证临床应用效果的同时能一定程度上缓解血液供应紧张的趋势,对提高整体治疗效果有积极意义,值得临床推广。
Objective:To investigate the therapeutic effects of different proportion of blood transfusion in the hospitalized patients with traumatic massive hemorrhage.Methods:96 cases with massive hemorrhage admitted to the emergency department of Ganzi Tibetan Autonomous Prefecture People's Hospital from March 2021 to March 2022 were selected as the study subjects,and were divided randomly into control group,observation group 1 and observation group 2 according to different proportions of their blood transfusion,each with 32 cases.The ratios of frozen plasma(FP)and suspended red blood cells(RBC)in blood transfusion in the control group,observation 1 group and observation 2 group were respectively≤1:2,>1:2-1:1,and>1:1;and the volume of FP and suspended RBC in the transfusion of the three groups was compared,and the following coagulation indexes of patients before and af⁃ter transfusion were also collected and compared:prothrombin time(PT),activated partial thromboplastin time(APTT),international normalized ratio(ISR)and international normalized ratio(INR).Results:The volumes of FP transfusion during hospital stay in pa⁃tients of the three groups showed a trend of sequential increase,and the difference was statistically significant(P<0.05);there was no statistically significant difference in comparison of volumes of suspended RBC transfusion in the three groups of patients(P>0.05).Before blood transfusion,PT,APTT and INR of the three groups of patients were compared,and the difference was not statistically significant(P>0.05);after blood transfusion,PT,APTT and INR of observation group 1 were lower than those of control group and ob⁃servation group 2,and the difference was statistically significant(P<0.05).Conclusion:For patients with traumatic massive hemor⁃rhage,the blood transfusion of FP and suspend RBC in ratio more than 1:2-1:1 can be given,which can effectively improve the coag⁃ulation dysfunction of the patients,and can compensate tense blood supply and therapeutic effect of blood transfusion.
作者
刘春梅
Liu Chunmei(Department of Blood Transfusion,Ganzi Tibetan Autonomous Prefecture People's Hospital,Kangding 626000,Sichuan Province,China)
出处
《中外医药研究》
2023年第26期42-44,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
外部创伤
大出血
成分输血
血液成分
凝血功能
External trauma
Massive hemorrhage
Component transfusion
Blood components
Coagulation function
