摘要
目的:探讨氯吡格雷联合阿司匹林治疗脑梗死的临床效果。方法:选取2022年3月—2023年3月上海市杨浦区殷行社区卫生服务中心收治的脑梗死患者40例,按照计算机随机分组方法分为对照组与观察组,各20例。对照组予以阿司匹林治疗,观察组采用氯吡格雷联合阿司匹林治疗。观察两组患者临床疗效,神经功能,日常活动能力,血液流变学指标(血浆黏度、血小板聚集率、全血黏度),C反应蛋白水平及不良反应情况。结果:两组患者治疗后观察组总有效率高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后神经功能评分、日常活动能力评分与治疗前比较,差异有统计学意义(P<0.05);观察组患者治疗后神经功能评分低于对照组,日常活动能力评分高于对照组,差异有统计学意义(P<0.05)。两组患者治疗后血浆黏度、血小板聚集率、全血黏度、C反应蛋白水平与治疗前比较,差异有统计学意义(P<0.05);观察组患者治疗后血浆黏度、血小板聚集率、全血黏度及C反应蛋白水平均低于对照组,差异有统计学意义(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论:对脑梗死患者采用氯吡格雷联合阿司匹林治疗,能改善患者的神经功能及血液流变学指标,提高日常活动能力,降低炎性反应,安全性高,值得应用并予以推广。
Objective:To investigate the clinical effect of clopidogrel combined with aspirin in the treatment of cerebral infarction.Methods:Forty patients with cerebral infarction admitted to Shanghai Yangpu District Yinhang Community Health Service Center from March 2022 to March 2023 were selected and divided into control group and observation group according to computer randomized method,with twenty patients in each group.The control group was treated with aspirin,the observation group was treated with clopidogrel combined with aspirin.The clinical efficacy,neurological function,daily activity ability,hemorheology indexes(plasma viscosity,platelet aggregation rate,whole blood viscosity),C-reactive protein level and adverse reactions of the two groups were observed.Results:After treatment,the total effective rate of observation group was higher than the control group,and the difference was statistically significant(P<0.05);The neurological function score and daily activity ability score after treatment were significantly different from those before treatment(P<0.05);After treatment,the neurological function score of observation group was lower than that of control group,and the daily activity ability score was higher than that of control group,the difference was statistically significant(P<0.05);The plasma viscosity,platelet aggregation rate,whole blood viscosity and C-reactive protein level of two groups after treatment were significantly different from those before treatment(P<0.05);After treatment,plasma viscosity,platelet aggregation rate,whole blood viscosity and C-reactive protein level in observation group were lower than those in control group,and the differences were statistically significant(P<0.05);There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Clopidogrel combined with aspirin in the treatment of cerebral infarction patients can improve the neurological function and hemorheology indexes of patients,improve daily activity ability,reduce infla
作者
黄惠敏
李爱花
Huang Huimin;Li Aihua(Shanghai Yangpu District Yinhang Community Health Service Center,Shanghai 200082,China)
出处
《中外医药研究》
2023年第25期60-62,共3页
JOURNAL OF CHINESE AND FOREIGN MEDICINE AND PHARMACY RESEARCH
关键词
脑梗死
氯吡格雷
阿司匹林
Cerebral infarction
Clopidogrel
Aspirin
