摘要
多囊卵巢综合征(polycystic ovary syndrome,PCOS)以排卵障碍、胰岛素抵抗和高雄激素血症为主要特征,是女性不孕症的主要原因之一。PCOS病因复杂,近年来许多研究表明其发病机制可能与慢性低度炎症有关。全身的慢性低度炎症通常与肥胖、胰岛素抵抗、高雄激素血症相互作用。卵巢局部存在的炎症可影响卵泡的发育和排卵。炎症除了影响生育功能以外,也会加重罹患其他疾病的风险,如非酒精性脂肪性肝病等。梳理PCOS患者体内肥胖、胰岛素抵抗、高雄激素血症与炎症之间复杂的关系,概述炎症在卵巢局部参与排卵障碍及生殖系统以外的疾病的机制。
Polycystic ovary syndrome(PCOS)is characterized by ovulatory dysfunction,insulin resistance,and hyperandrogenemia,and is one of the main causes of female infertility.Its etiology is complex,and many studies in recent years have shown that its pathogenesis may be related to low-grade chronic inflammation.Systemic low-grade chronic inflammation is often associated with obesity,insulin resistance and hyperandrogenemia.Inflammation in the ovaries can affect follicular development and ovulation.In addition to affecting reproductive function,inflammation also increases the risk of other diseases,such as non-alcoholic fatty liver disease.This article provides a detailed overview of the complex relationship between obesity,insulin resistance,hyperandrogenemia,and inflammation in PCOS patients,and outlines how inflammation is involved in ovulatory disorders and the diseases outside the reproductive system.
作者
曲慧颖
桂文武(审校)
QU Hui-ying;GUI Wen-wu(Reproductive Medicine Center,The First Affiliated Hospital of Chongqing Medical University,Chongqing 400042,China)
出处
《国际生殖健康／计划生育杂志》
CAS
2024年第1期48-52,共5页
Journal of International Reproductive Health/Family Planning
基金
重庆市渝中区基础研究与前沿探索项目(20210118)。
