摘要
目的:探究子宫肌瘤术后复发高危因素,提出预防对策.方法:回顾性分析本院2020年1月-2022年3月行手术治疗的子宫肌瘤患者200例临床资料,根据随访术后1年复发与否分为复发组和未复发组,单因素及多因素logistic回归分析术后子宫肌瘤复发高危因素.结果:子宫肌瘤术后1年复发率15.0%.复发组与非复发组体质指数、子宫肌瘤直径及数目、术后1年雌二醇(E_(2))、卵泡雌激素(FSH)、黄体生成素(LH)及癌胚抗原-125(CA125)、结缔组织生长因子(CTGF)水平有差异(均P<0.05);logistic多因素回归分析显示,子宫肌瘤数目>2个、术后1年FSH、LH、CA125及CTGF高水平是术后1年复发的独立危险因素(P<0.05),术后1年E_(2)高水平为保护因素(P<0.05).术后1年CA125、CTGF水平预测子宫肌瘤术后1年复发的曲线下面积(AUC)分别为0.726、0.921.结论:子宫肌瘤患者术后复发高危因素有肌瘤多发、性激素指标异常及血清CA125、CTGF高表达,需加强上述因子监测,针对性干预以减少术后复发风险.
Objective:To explore the high-risk factors of postoperative recurrence of the uterine myoma。and to Put forward the preventive measures.Methods:The clinical data of 200 patients with uterine myomas who had undergone surgical treatment in the hospital from January 2020 to March 2022 were analyzed retrospectively.According to whether the patients with recurrence of the uterine myomas or not in 1 year of follow-up after surgery,these patients were divided in group A(patients with the recurrence of the uterine myomas)and group B(patients without the recurrence of the uterine myomas).The high-risk factors of the postoperative recurrence of the uterine myomas were analyzed by univariate and multivariate Logistic regression.Results:The recurrence rate of uterine myomas of the patients within 1-year after surgery was 15.0%.There were significant differences in the body mass index,the diameter and number of uterine myomas,and the levels of estradiol(E_(2)),fllile estrogen(FSH),luteinizing hormone(LH).carcinoembryonic antigen-125(CA125)and connective tissue growth factor(CTGF)of the patients between the two groups(all P<0.05).Multivariate logistic regression analysis showed that the number of uterine myoma>2。the high levels of FSH,LH.CA125 and CTGF of the patients in 1 year after surgery were the independent risk factors of their uterine myoma recurrence(P<0.05),and the high level of E_(2) of the patients in 1 year after surgery was a protective factor of their uterine myoma recurrence(P<0.05).The area under the curve(AUC)of the CA125 and CTGF levels of the patients in 1 year after surgery for predicting the recurrence of their uterine myoma in 1 year after surgery was 0.726 and 0.921.Conclusion:The highrisk factors of the postoperative uterine myoma recurrence of the patients include the multiple uterine myoma,the abnormal sex hormone indexes levels and the high expressions of serum CA125 and CTGF,and which should be strengthen monitoring and the targeted intervention should be conducted to reduce the risk of the posto
作者
杨健
李倩
YANG Jian;LI Qian(Linhai Maternal and Child Health Care Hospital,Linhai,Zhejiang Province,317000)
出处
《中国计划生育学杂志》
2024年第1期167-171,共5页
Chinese Journal of Family Planning
关键词
子宫肌瘤手术
术后1年复发
高危因素
预防对策
Uterine myomas surgery
Recurrence in 1 year after surgery
High-risk factor
Preventive strategy
