摘要
目的探讨尖锐湿疣患者皮损组织中自噬相关基因3(ATG3)与自噬相关基因5(ATG5)的表达水平及临床意义。方法选取青岛市城阳区人民医院收治的92例尖锐湿疣患者作为研究组。选取同期因其他原因切除外生殖器正常皮肤组织的63例健康者作为对照组,其中45例男性行包皮环切术,18例女性行外阴整形术。收集并记录所有研究对象的一般资料,检测皮损组织中ATG3和ATG5的表达水平,采用Pearson法分析ATG3和ATG5表达水平的相关性,采用受试者工作特征(ROC)曲线分析ATG3、ATG5表达水平预测尖锐湿疣复发的效能。结果研究组患者皮损组织中ATG3(1.28±0.27)和ATG5(0.91±0.23)表达水平较对照组(1.86±0.39,1.34±0.31)显著降低(P<0.05)。皮损组织ATG3和ATG5表达水平与疣体团块直径及人乳头瘤病毒(HPV)类型有关(P<0.05)。Pearson法相关分析显示,尖锐湿疣患者皮损组织中ATG3和ATG5表达水平呈正相关(r=0.527,P<0.05)。复发组皮损组织中ATG3和ATG5表达水平显著低于未复发组(P<0.05)。皮损组织中ATG3、ATG5单独及联合预测尖锐湿疣复发的AUC分别为0.729、0.785和0.907,二者联合优于ATG3、ATG5单一指标预测(Z_(ATG3-联合)=2.876、Z_(ATG5-联合)=2.064,P<0.05)。结论ATG3和ATG5在尖锐湿疣患者皮损组织中表达水平显著降低,二者联合可用于预测尖锐湿疣的复发,临床应用价值较大。
Objective To investigate the expression levels and clinical significance of autophagyrelated gene 3(ATG3)and autophagy-related gene 5(ATG5)in skin lesions of patients with condyloma acuminatum.Methods A total of 92 patients with condyloma acuminatum admitted to Chengyang District People's Hospital were selected as the study group.A total of 63 healthy people with normal skin tissue removed for other reasons during the same time were regarded as the control group,among them,45 cases were males undergoing circumcision and 18 cases were females undergoing vulvoplasty.General information of all subjects was collected and recorded,the expression levels of ATG3 and ATG5 were detected.The correlation between the expression levels of ATG3 and ATG5 was analyzed by Pearson method.The efficacy of ATG3 and ATG5 expression levels in predicting the recurrence of condyloma acuminatum was analyzed by receiver operating characteristic(ROC)curve.Results The expression levels of ATG3(1.28±0.27)and ATG5(0.91±0.23)in the skin lesions of patients in the study group were significantly lower than those in the control group(1.86±0.39,1.34±0.31)(P<0.05).The expression levels of ATG3 and ATG5 in skin lesions were correlated to the diameter of wart mass and human papilloma virus(HPV)type(P<0.05).Pearson correlation analysis showed that the expression levels of ATG3 and ATG5 in the skin lesions of patients with condyloma acuminatum were positively correlated(r=0.527,P<0.05).The expression levels of ATG3 and ATG5 in the skin lesions of the recurrence group were significantly lower than those of the non-recurrence group(P<0.05).The area under ROC curve(AUC)of ATG3 and ATG5 alone and combined in predicting the recurrence of condyloma acuminatum was 0.729,0.785 and 0.907,respectively,the combination of them was better than that of ATG3 and ATG5 alone(Z_(ATG3-combination)=2.876,Z_(ATG5-combination)=2.064,P<0.05).Conclusions The expression levels of ATG3 and ATG5 in the skin lesions of patients with condyloma acuminatum are significantly decre
作者
王泽淑
王万军
匡乃峰
WANG Zeshu;WANG Wanjun;KUANG Naifeng(Department of Dermatology,Chengyang District People's Hospital,Qingdao 266109,Shandong,China)
出处
《中国性科学》
2024年第1期148-152,共5页
Chinese Journal of Human Sexuality
基金
泰安市科技发展计划引导项目(2018NS0224)。
关键词
尖锐湿疣
自噬相关基因3
自噬相关基因5
复发
Condyloma acuminatum
Autophagy-related gene 3
Autophagy-related gene 5
Recurrence
