摘要
目的探讨重组α-2b干扰素联合常规药物对病毒感染所致老年慢性支气管炎(CB)急性发作的疗效。方法选取2019年6月至2021年4月浙江省台州市中医院收治的病毒感染所致老年CB急性发作患者120例,按治疗方法分为对照组(常规药物规范治疗,60例)和研究组(重组α-2b干扰素+常规药物规范治疗,60例)。将肺功能、临床疗效、炎症反应因子、动脉血气与不良反应作为评价指标。结果2组患者第1秒用力呼气容积(FEV_(1))、用力肺活量(FVC)、FEV_(1)/FVC、氧分压(PaO_(2))、血氧饱和度(SaO_(2))经治疗均升高(P<0.05),且研究组较对照组高(P<0.05);2组患者临床疗效差异有统计学意义,且研究组总有效率更高(P<0.05);2组患者白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、超敏C-反应蛋白(hs-CRP)、二氧化碳分压(PaCO_(2))经治疗前均下降(P<0.05),且研究组较对照组低(P<0.05);2组患者不良反应发生率差异无统计学意义(P>0.05)。结论重组α-2b干扰素联合常规药物治疗较单纯常规药物治疗可改善病毒感染所致老年CB急性发作患者的肺功能、增强疗效、降低促炎症因子水平、改善动脉血气,且未发现增加不良反应。
Objective To investigate the efficacy of recombinantα-2b interferon combined with conven-tional drugs in the treatment of acute exacerbation of chronic bronchitis(CB)in the elderly caused by viral infec-tion.Methods A total of 120 elderly patients with acute exacerbation of CB due to viral infection in Taizhou Traditional Chinese Medicine Hospital from June 2019 to April 2021 were selected and randomly divided into the control group(standarded treatment of conventional drugs,60 cases)and the study group(recombinantα-2b inter-feron and standardized treatment of conventional drugs,60 cases).The pulmonary function,clinical efficacy,in-flammatory response factors,arterial blood gas and adverse reactions were used as evaluation indexes.Results Forced expiratory volume in the first second(FEV_(1)),forced vital capacity(FVC),FEV_(1)/FVC,arterial partial pres-sure of oxygen(PaO_(2))and arterial oxygen saturation(SaO_(2))were increased in both groups after treatment(P<0.05),which were higher in the study group(P<0.05).The difference in the distribution of clinical efficacy between the two group was statistical(P<0.05),and the total effective rate in the study group was higher(P<0.05).The levels of interleukin-6(IL-6),interleukin-8(IL-8),hypersensitive C-reactive protein(hs-CRP),arterial partial pressure of carbon dioxide(PaCO_(2))in the two groups decreased after treatment(P<0.05),which were lower in the study group(P<0.05),the incidence of adverse reactions in both the two groups(P>0.05).Conclusion Compared with con-ventional drug therapy alone,recombinationα-2b interferon combined with conventional drug treatment can im-prove the lung function,enhance the curative effect,reduce the levels of pro-inflammatory factors,and improve the arterial blood gases in elderly patients with acute attack of CB caused by viral infection,and it will not significant-ly increase adverse reactions.
作者
陈苍宋
张君利
贺洁
陶毅强
Chen Cangsong;Zhang Junli;HeJie;Tao Yiqiang(Department of Respiratory and Critical Care Medicine,Taizhou Traditional Chinese Medicine Hospital,Taizhou,Zhejiang 318000,China)
出处
《中国药物与临床》
2023年第8期492-496,共5页
Chinese Remedies & Clinics
基金
浙江省台州市科技计划项目(21ywb69)。
