摘要
目的观察丙种球蛋白联合阿司匹林治疗小儿川崎病(KD)的临床疗效。方法回顾性选择2018年5月—2021年5月石狮市妇幼保健院和晋江市妇幼保健院收治的KD患儿50例,根据治疗方案不同分为联合用药组和阿司匹林组,每组25例。联合用药组采用丙种球蛋白联合阿司匹林治疗,阿司匹林组采用阿司匹林治疗。比较2组疗效、症状改善时间,治疗前后炎性指标[红细胞沉降率(ESR)、降钙素原(PCT)、C反应蛋白(CRP)]、血小板计数(PLT)、T淋巴细胞亚群、血管内皮生长因子(VEGF)及治疗期间不良反应。结果联合用药组治疗总有效率高于阿司匹林组(96.00%vs.68.00%,χ^(2)=4.878,P=0.027)。联合用药组皮疹、手足肿胀、黏膜充血消退时间及退热时间短于阿司匹林组(P<0.01)。治疗后,2组ESR、PCT、CRP及PLT水平较治疗前降低,且联合用药组低于阿司匹林组(P<0.01);2组CD4^(+)及VEGF水平较治疗前降低,CD8^(+)水平较治疗前升高,且联合用药组变化幅度大于阿司匹林组(P<0.05或P<0.01)。联合用药组不良反应总发生率为12.00%,阿司匹林组不良反应总发生率为8.00%,2组比较差异无统计学意义(P=1.000)。结论丙种球蛋白联合阿司匹林治疗小儿KD效果显著,可明显减轻机体炎性反应,加快症状改善,且安全性较高。
Objective To observe the clinical efficacy of gamma globulin combined with aspirin in the treatment of pediatric Kawasaki disease(KD).Methods Fifty cases of KD children admitted to Shishi Maternity and Child Health Care Hospital and Jinjiang Maternal and Child Health Care Hospital from May 2018 to May 2021 were retrospectively selected,and they were divided into combination therapy group and aspirin group according to different treatment schemes,with 25 cases in each group.The combination therapy group was treated with gamma globulin combined with aspirin,while the aspirin group was treated with aspirin.The clinical efficacy,symptom improvement time,inflammatory indexes(ESR,PCT,CRP),PLT,T-lymphocyte subsets,VEGF before and after treatment,and adverse reactions during treatment were compared between the two groups.Results The total effective rate of the combination therapy group was higher than that of the aspirin group(96.00%vs.68.00%,χ^(2)=4.878,P=0.027).The time for the rash,hand and foot swelling,mucosal congestion to subside and the time for fever to subside in the combination therapy group were shorter than those in the aspirin group(P<0.01).After treatment,the levels of ESR,PCT,CRP,and PLT in the two groups decreased compared to before treatment,and the combination therapy group were lower than those of the aspirin group(P<0.01);The levels of CD4^(+) and VEGF in the two groups decreased compared to before treatment,while the levels of CD8^(+) increased compared to before treatment,and the combination therapy group had a greater degree of change than the aspirin group(P<0.05 or P<0.01).The total incidence of adverse reactions in the combination therapy group was 12.00%,while the total incidence of adverse reactions in the aspirin group was 8.00%,there was no statistically significant difference between the two groups(P=0.001).Conclusion The combination of gamma globulin and aspirin has a significant therapeutic effect on pediatric KD,which can significantly reduce the inflammatory response of the body,accel
作者
高铧炜
吴松
GAO Huawei;WU Song(Shishi Maternity and Child Health Care Hospital,Fujian Province,Shishi 362700,China;不详)
出处
《临床合理用药杂志》
2024年第2期27-30,共4页
Chinese Journal of Clinical Rational Drug Use
关键词
川崎病
丙种球蛋白
阿司匹林
疗效
血管内皮生长因子
Kawasaki disease
Gamma globulin
Aspirin
Efficacy
Vascular endothelial growth factor
