摘要
病原微生物通过特殊的分泌系统向宿主释放一系列效应蛋白,干扰宿主的先天免疫相关信号通路,引起疾病的发生甚至导致宿主死亡,是病原微生物致病的重要手段。翻译后修饰在病原微生物感染过程中发挥重要功能,受到越来越多重视,其中,磷酸化修饰是一种常见的翻译后修饰,迄今为止许多效应蛋白被发现具有丝氨酸/苏氨酸激酶活性。微生物借助于这些具有激酶活性的效应蛋白,将宿主内特异靶蛋白进行磷酸化修饰,进而干扰宿主细胞内的信号转导功能,抑制宿主免疫防御反应,促进病原微生物在宿主体内的繁殖与扩增。对近期发现的具有激酶活性的效应蛋白进行概述,为进一步理解磷酸化修饰介导的病原微生物感染以及药物靶标选择提供参考。
Pathogenic microorganisms release a series of effector proteins to their hosts through a special secretion system,which can interfere with the host's innate immunity-related signaling pathways,causing the occurrence of disease and even leading to the host's deaths,which is an important means for their virulence.It is widely realized that post-translational modifications mediated by effectors play a crucial role in the process of pathogenic microbial infections.Phosphorylation is one of the most common post-translational modifications,which is achieved by kinases,and many effector proteins in numerous pathogenic microorganisms have been found to have serine/threonine kinase activity so far.With the help of these efficient effector proteins with kinase activity,pathogenic microorganisms can phosphorylate host-specific target proteins,thereby interfering with their normal signal transduction in host cells,leading to the inhibition of host immune defense responses,causing serious harm to the host,and promoting the reproduction and expansion of pathogenic microorganisms in the host.This study provides an overview of recently identified effector proteins with kinase activity in pathogenic microorganisms,offering a reference for a better understanding of phosphorylation modification-mediated pathogenic microbial infection and guiding drug design for the treatment of pathogenic microorganism infections.
作者
林念念
甄向凯
欧阳松应
LIN Niannian;ZHEN Xiangkai;OUYANG Songying(College of Life Sciences,Fujian Normal University,Fuzhou 350117,China;Biomedical Research Center of South China,Fujian Normal University,Fuzhou 350117,China)
出处
《福建师范大学学报（自然科学版）》
CAS
北大核心
2024年第1期14-22,33,共10页
Journal of Fujian Normal University：Natural Science Edition
基金
国家自然科学基金资助项目(32170045、82225028)。
关键词
病原微生物
翻译后修饰
效应蛋白
丝氨酸/苏氨酸激酶
pathogenic microorganisms
post-translational modifications
effector proteins
serine/threonine kinase
