摘要
二型炎症反应主要由二型免疫细胞和二型细胞因子介导,例如二型辅助型T细胞(Th2细胞)和二型先天样淋巴细胞(ILC2细胞),以及IL-4、IL-5、IL-13等。二型炎症反应在体液免疫、抗寄生虫、中和毒素、组织损伤修复和再生等过程中发挥重要调控作用,但其也有促进疾病发生的作用。目前认为二型炎症反应主要在皮肤、呼吸道、消化道和脂肪等组织中发挥生理和病理性作用,是导致过敏性疾病发生的主要炎症反应类型。呼吸道由于其特殊的免疫微环境,是二型炎症高发区域,涉及的疾病包括慢性鼻窦炎、过敏性鼻炎、过敏性哮喘、过敏性支气管肺曲霉菌病、嗜酸性粒细胞增多的慢性阻塞性肺疾病等。本文将重点综述二型炎症反应中的关键免疫细胞Th2和ILC2细胞在肺部过敏性炎症中的最新研究进展和过敏性炎症相关疾病靶向治疗的情况。
The typeⅡinflammatory response is primarily mediated by type 2 immune cells and cytokines,such as helper 2 cells(Th2)and group 2 innate lymphoid cells(ILC2),along with IL-4,IL-5 and IL-13.This response plays crucial roles in humoral immunity,parasite defense,toxin neutralization,tissue damage repair and regeneration.However,type-Ⅱimmune response can also contribute to the development of diseases.Currently,typeⅡinflammation is recognized to have physiological and pathological implications in the skin,respiratory tract,digestive tract and adipose tissues.Moreover,it serves as a major cause of allergic diseases.Due to its unique immune microenvironment,the respiratory tract exhibits a high prevalence of typeⅡinflammation encompassing chronic sinusitis,allergic rhinitis,allergic asthma,allergic bronchopulmonary aspergillosis,and chronic obstructive pulmonary disease with eosinophilia among others.This review will focus on the research progress concerning Th2 and ILC2 cells in allergic pulmonary inflam‐mation as well as targeted therapy for allergic diseases.
作者
张亚光
孙兵
ZHANG Yaguang;SUN Bing(Med-X Institute,Center for Immunological and Metabolic Diseases,the FirstAffiliated Hospital of Xi'an JiaoTong University,Xi'an 710049,China;Center for Excellence in Molecular CellScience,Chinese Academy of Sciences,Shanghai 200031,China)
出处
《中国免疫学杂志》
CAS
CSCD
北大核心
2024年第1期11-20,共10页
Chinese Journal of Immunology
