摘要
光声成像技术是一种集光学成像与声学成像技术优势为一体的无创成像手段。这种成像手段具有高的空间分辨率及深层组织穿透性能,在生物医学研究及临床应用领域中展现出巨大的应用潜力。近年来,为提高光声成像的实时诊断能力,研究者们开发了一系列刺激响应型光声成像探针,用于体内特定生物学事件的动态可视化示踪。该综述从刺激响应型光声探针的设计策略出发,并以内源性刺激源(如pH、酶、自由基等)及外源性刺激源(如光、温度、超声等)为分类,重点介绍当前光声成像在体内的研究进展。同时,对激活型光声成像技术的未来发展趋势进行展望,为光声成像探针的开发提供了参考。
Photoacoustic(PA)imaging,a promising imaging technology that integrates characteris-tics of optical imaging with acoustic imaging,enables non-invasive imaging modality with high spatio-temporal resolution and deep tissue penetration.Thus,PA imaging has shown great potential in bio-medical and clinical applications.In recent years,to dynamically visualize the specific biological process in vivo,a series of stimuli-responsive photoacoustic nanoagents are develpoed with better re-al-time diagnostic capability.Those PA imaging agents possess activable PA intensities in responding to specific stimuli.From this perspective,this review will summarize the general strategies and re-cent advances for developing stimuli-responsive PA nanoagents,including internal stimuli,such as pH,enzyme,free radical,ect,as well as external stimuli,such as light,thermal,ultrasound,ect.Furthermore,current challenges and outlooks for developing activable PA nanoagents will be discussed.
作者
袁茜
李一荣
YUAN Xi;LI Yi-rong(Department of Laboratory Medicine,Zhongnan Hospital of Wuhan University,Wuhan 430071,China)
出处
《分析测试学报》
CAS
CSCD
北大核心
2024年第1期166-173,共8页
Journal of Instrumental Analysis
基金
武汉大学中南医院优秀博士(后)资助项目(ZNYB2022009)
武汉大学中南医院科技创新培育基金(CXPY2023027)。
关键词
光声成像
纳米探针
刺激响应型
生物医学
photoacoustic imaging
nanoagents
stimuli-responsive
biomedicine
