摘要
目的探讨血清脑钠肽(BNP)、降钙素原(PCT)、可溶性生长刺激表达因子2(sST2)与急性左心力衰竭(简称心衰)患者超声心功能指标的相关性。方法选取2019年1月至2021年12月该院收治的83例急性左心衰患者作为观察组,另选取同期该院40例健康体检者作为对照组。比较观察组和对照组BNP、PCT、sST2、左室射血分数(LVEF)、左心室舒张末期内径(LVEDD)和左房内径(LAD)水平;采用受试者工作特征(ROC)曲线分析BNP、PCT、sST2对急性左心衰的诊断价值;比较不同心功能分级患者BNP、PCT、sST2、LVEF、LVEDD、LAD水平;采用Pearson相关分析血清BNP、PCT、sST2与急性左心衰患者心功能指标的相关性。结果观察组BNP、PCT、sST2、LVEDD、LAD水平均明显高于对照组,LVEF水平明显低于对照组,差异均有统计学意义(P<0.05)。ROC曲线分析结果显示,BNP、PCT、sST2诊断急性左心衰的曲线下面积分别为0.877、0.887、0.850。随着心功能分级上升,急性左心衰患者BNP、PCT、sST2水平明显上升,LVEF水平明显下降,Ⅳ级患者LVEDD水平明显高于Ⅱ级患者,Ⅲ级、Ⅳ级患者LAD水平均明显高于Ⅱ级患者,差异均有统计学意义(P<0.05)。BNP、PCT、sST2与LVEF均呈负相关(P<0.05),与LVEDD、LAD均呈正相关(P<0.05)。结论血清BNP、PCT、sST2与急性左心衰患者心功能指标之间存在一定的相关性,其中BNP、PCT、sST2与LVEF均呈负相关,与LVEDD、LAD均呈正相关。
Objective To investigate the correlation between serum brain natriuretic peptide(BNP),procalcitonin(PCT),soluble growth stimulation expression factor 2(sST2)and echocardiographic cardiac function indexes in patients with acute left heart failure(heart failure).Methods A total of 83 patients with acute left heart failure admitted to the hospital from January 2019 to December 2021 were selected as the observation group,and 40 healthy people in the same hospital during the same period were selected as the control group.The levels of BNP,PCT,sST2,left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD)and left atrial diameter(LAD)were compared between the observation group and the control group.Receiver operating characteristic(ROC)curve was used to analyze the diagnostic value of BNP,PCT and sST2 for acute left heart failure.The levels of BNP,PCT,sST2,LVEF,LVEDD and LAD in patients with different cardiac function grades were compared.Pearson correlation analysis was used to analyze the correlation between serum BNP,PCT,sST2 and cardiac function in patients with acute left heart failure.Results The levels of BNP,PCT,sST2,LVEDD and LAD in the observation group were significantly higher than those in the control group,and the level of LVEF was significantly lower than that in the control group,the differences were statistically significant(P<0.05).ROC curve analysis showed that the area under the curve of BNP,PCT and sST2 for the diagnosis of acute left heart failure was 0.877,0.887 and 0.850 respectively.With the increase of cardiac function classification,the levels of BNP,PCT and sST2 in patients with acute left heart failure increased significantly,and the level of LVEF decreased significantly.The level of LVEDD in patients with gradeⅣwas significantly higher than that in patients with gradeⅡ,and the level of LAD in patients with gradeⅢandⅣwas significantly higher than that in patients with gradeⅡ,and the differences were statistically significant(P<0.05).BNP,PCT and sST2 we
作者
曾能初
ZENG Nengchu(Department of Emergency,Suichuan People′s Hospital,Ji′an,Jiangxi 343900,China)
出处
《检验医学与临床》
CAS
2024年第2期257-260,共4页
Laboratory Medicine and Clinic
关键词
心力衰竭
脑利钠肽
可溶性生长刺激表达因子2
左室射血分数
降钙素原
heart failure
brain natriuretic peptide
soluble growth stimulation expression factor 2
left ventricular ejection fraction
procalcitonin
