摘要
目的探讨生化汤联合卡前列素氨丁三醇预防剖宫产产后出血的临床研究。方法选取2019年1月—2022年3月期间南阳市中心医院收治的行剖宫产后出血患者300例作为研究对象,按随机数字表法分为对照组和观察组,每组各150例。对照组予以卡前列素氨丁三醇治疗,观察组在对照组基础上联合生化汤治疗。持续治疗7 d后,观察比较两组患者临床疗效、出血情况、血压情况、氧化应激指标[脂质过氧化物(Lipid hydroperox-ide,LPO)、超氧化物歧化酶(Superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(Glutathione peroxidase,GSH-Px)]及并发症发生情况。结果治疗后观察组临床总有效率96.00%(144/150)高于对照组90.00%(135/150),差异有统计学意义(P<0.05)。治疗后观察组出血时间明显短于对照组,差异有统计学意义(P<0.05);术中出血量及术后24 h出血量明显少于对照组,差异有统计学意义(P<0.05);观察组后期出血率明显低于对照组,差异有统计学意义(P<0.05)。两组患者治疗前后收缩压、舒张压、心率比较,差异无统计学意义(P>0.05)。治疗后两组患者血清LPO水平较治疗前降低,SOD、GSH-Px水平较治疗前升高,差异有统计学意义(P<0.05);且观察组血清LPO水平低于对照组,SOD、GSH-Px水平高于对照组,差异有统计学意义(P<0.05)。治疗后观察组并发症总发生率5.33%(8/150)明显低于对照组13.33%(20/150),差异有统计学意义(P<0.05)。结论剖宫产产后出血患者应用生化汤联合卡前列素氨丁三醇治疗的临床效果显著,能有效减少其氧化应激反应,预防和治疗产后出血且不影响血压和心率,降低产后出血量,缩短止血时间。
Objective To investigate the clinical efficacy of Shenghua Decoction combined with carboprost tromethamine in preventing postpartum hemorrhage in patients undergoing cesarean section.Method From January 2019 to March 2022,300 patients with postpartum hemorrhage after cesarean section in Nanyang Central Hospital were selected as the research objects,and they were randomly divided into control group and observation group,with 150 cases in each group.The patients in the control group received treatment with carboprost tromethamine,and the patients in the observation group were treated with Shenghua Decoction combined with carboprost tromethamine.After 7 days of continuous treatment,the clinical efficacy,bleeding,blood pressure,oxidative stress indicators[lipid hydroperoxide(LPO),superoxide dismutase(SOD),glutathione peroxidase(GSH-Px)]and the occurrence of complications were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was 96.00%(144/150),which was higher than the control group′s rate of 90.00%(135/150),and the difference was statistically significant(P<0.05).The bleeding time in the observation group was shorter than that in the control group(P<0.05).The intraoperative blood loss and 24-hour postoperative blood loss in the observation group were significantly less than those in the control group(P<0.05).The late bleeding rate in the observation group was significantly lower than that in the control group,with a statistically significant difference(P<0.05).There were no statistically significant differences in systolic blood pressure,diastolic blood pressure,and heart rate between the two groups before and after treatment(P>0.05).After 7 days of treatment,both groups showed a decrease in serum LPO level and an increase in SOD and GSH-Px levels compared to before treatment(P<0.05).Furthermore,the observation group had lower serum LPO level and higher SOD and GSH-Px levels than the control group,with statistically significant differences(P<0.05).T
作者
兰岚
姚利
曾仪
LAN Lan;YAO Li;ZENG Yi(Obstetrics Department of Nanyang Central Hospital,Nanyang Henan 473000;Center of Genetics and Prenatal Diagnosis,the First Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450000)
出处
《世界中西医结合杂志》
2023年第11期2264-2267,2274,共5页
World Journal of Integrated Traditional and Western Medicine
基金
2019年河南省医学科技攻关计划联合共建项目(LHGJ20191187)。
关键词
生化汤
卡前列素氨丁三醇
剖宫产
产后出血
Shenghua Decoction
Carboprost Tromethamine
Cesarean Section
Postpartum Hemorrhage
