摘要
目的观察缓和医疗干预晚期阿尔茨海默病患者的效果。方法2021年1月~2022年12月收治的晚期阿尔茨海默病患者60例,随机分为观察组与对照组各30例。两组均予常规医疗,观察组在此基础上结合缓和医疗。比较两组干预前后严重损害量表(Severe Impairment Battery,SIB)、日常生活能力量表(Activity of Daily Living Scale,ADL)、全面衰退量表(Global Deterioration Scal,GDS),神经精神科问卷(Neuropsychiatric Inventory Questionnaire,NPI),中文版晚期老年痴呆症疼痛评估量表(Chinese Pain Assessment in Advanced Dementia Scale,C-PAINAD),晚期痴呆患者生活质量量表(Quality of Life in Late Stage Dementia Scale,QUALIDS),照料者负担量表(Zarit Burden Interview,ZBI)。结果干预后观察组及对照组SIB、ADL、GDS评分差异无统计学意义(P>0.05)。干预后观察者NPI评分低于对照组,差异有统计学意义(P<0.05)。干预后观察组C-PAINAD、QUALIDS、ZBI评分低于对照组,差异有显著统计学意义(P<0.01)。结论缓和医疗虽不能改善晚期阿尔茨海默病患者认知功能及日常生活能力,但可以改善晚期阿尔茨海默病患者精神行为症状,明显改善躯体疼痛、提高生存质量、减少照料者负担。
Objective To observe the effect of palliative medical intervention on patients with advanced Alzheimer's disease.Methods Sixty patients with advanced Alzheimer's disease admitted from January 2021 to December 2022 were randomly divided into an observation group and a control group,with 30 patients in each group.Both groups received routine medical treatment,while the observation group received palliative care on this basis.Compare the two groups of Severe Impairment Battery(SIB),Activity of Daily Living Scale(ADL),Global Deterioration Scale(GDS),Neuropsychiatric Inventory Questionnaire(NPI),and Chinese Version of Pain Assessment in Advanced Dementia Scale C-PAINAD before and after intervention,Quality of Life in Late Stage Dementia Scale(QUALIDS)and Zarit Burden Interview(ZBI)for patients with advanced dementia.Results After the intervention,there was no statistically significant difference in SIB,ADL,and GDS scores between the observation group and the control group(P>0.05).After intervention,the NPI score of the observer was lower than that of the control group,and the difference was statistically significant(P<0.05).After intervention,the C-PAINAD,QUALIDS,and ZBI scores of the observation group were lower than those of the control group,and the difference was statistically significant(P<0.01).Conclusion Although palliative medicine cannot improve cognitive function and daily living ability of patients with advanced Alzheimer's disease,it can improve their mental and behavioral symptoms,significantly improve physical pain,improve quality of life,and reduce caregiver burden.
作者
陈非
陈恳
袁刚
蒋平静
CHEN Fei;CHEN Ken;YUAN Gang(Chongqing Mental Health Center,Chongqing 400000,China)
出处
《国际精神病学杂志》
2023年第6期1419-1422,共4页
Journal Of International Psychiatry
基金
重庆市科卫联合医学科研项目(编号:2021MSXM252)。
关键词
缓和医疗
晚期阿尔茨海默病
生存质量
Palliative care
Advanced Alzheimer's disease
Quality of Life
