摘要
目的探讨双相情感障碍躁狂发作患者联合应用丙戊酸钠与喹硫平治疗的临床效果。方法于2021年1月~2023年1月采集病例资料入档,对象为医院收治的双相情感障碍躁狂发作患者,共计纳入80例,纳入对象基于“随机数字表法”规范化分组,划分为对照组(予以丙戊酸钠治疗)与观察组(应用丙戊酸钠+喹硫平治疗),各组均40例;观察对比两组临床疗效、阳性及阴性症状(PANSS)、躁狂评分、和不良反应发生率。结果观察组治疗总有效率较对照组显著高(P<0.05);治疗后,两组贝克-拉范森躁狂评定量表(BRMS)、呈不同程度降幅,且观察组降幅较对照组更大(P<0.05);治疗后,两组PANSS评分均呈下降趋势,且观察组更低(P<0.05);两组患者不良反应发生率无明显差异(P>0.05)。结论双相情感障碍躁狂发作患者合用丙戊酸钠与喹硫平治疗,可取得确切疗效,且不良反应少,安全性好。
Objective To explore the clinical effect of the combination of sodium valproate and Quetiapine in the treatment of manic episode patients with bipolar affective disorder.Methods From January 2021 to January 2023,case data were collected and filed.The subjects were manic episode patients with bipolar affective disorder admitted to the hospital.A total of 80 cases were included.The included subjects were divided into control group(treated with sodium valproate)and observation group(treated with sodium valproate and Quetiapine)based on the standardized grouping of"random number table",with 80 cases in each group.The clinical efficacy,positive and negative symptoms(PANSS),manic score and incidence of adverse reactions between the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group(P<0.05).After treatment,the scores of the Beck Ravensen Mania Rating Scale(BRMS)and Hamilton Depression Rating Scale(HAMD)in both groups showed varying degrees of decline,and the observed group had a greater decrease than the control group(P<0.05).After treatment,the PANSS scores of both groups showed a downward trend,and the observation group showed a lower trend(P<0.05).Comparison of adverse reaction rates between two groups of patients(P>0.05).Conclusion The combination of sodium valproate and Quetiapine in the treatment of manic episode patients with bipolar affective disorder can achieve definite efficacy,with less adverse reactions and good safety.
作者
冯仁健
陈前文
王华胜
FENG Renjian;CHEN Qianwen;WANG Huasheng(Xuancheng People's Hospital,Xuancheng 24200,China)
出处
《国际精神病学杂志》
2023年第6期1376-1379,共4页
Journal Of International Psychiatry
