摘要
目的探讨血清CD4^(+)/CD8^(+)T淋巴细胞比值结合磁共振血管造影(MRA)与脑梗死再发的相关性及预测作用。方法选取镇江市第一人民医院2021年1月至2022年2月收治的急性脑梗死患者153例,测定患者CD4^(+)/CD8^(+)T淋巴细胞比值,MRA评估血管狭窄评分、侧支循环充盈评分,对患者进行1年随访,其中34例脑梗死再发患者作为脑梗死再发组,107例脑梗死未再发患者作为脑梗死未再发组,排除其他各种原因失访12例患者,并绘制各指标用于预测患者脑梗死再发的受试者工作特征(ROC)曲线。结果脑梗死再发组CD4^(+)/CD8^(+)T淋巴细胞比值明显高于脑梗死未再发组(P<0.05);脑梗死再发组血管狭窄评分、侧枝循环充盈评分均低于脑梗死未再发组(P<0.05)。患者脑梗死再发与CD4^(+)/CD8^(+)T淋巴细胞比值、血管狭窄评分、侧枝循环充盈评分均有关(P<0.05)。ROC曲线分析显示,CD4^(+)/CD8^(+)T淋巴细胞比值、血管狭窄评分、侧枝循环充盈评分预测患者脑梗死再发的曲线下面积(AUC)分别为0.975、0.889、0.935,三者联合预测患者脑梗死再发的AUC为0.994,显著高于各指标单独预测患者脑梗死复发的AUC。结论血清CD4^(+)/CD8^(+)T淋巴细胞比值结合MRA血管狭窄评分、侧支循环充盈评分诊断脑梗死再发效能较高,对脑梗死再发具有预测价值。
Objective To investigate the correlation and predictive effect of serum CD4^(+)/CD8^(+)T lymphocyte ratio combined with magnetic resonance angiography(MRA)on recurrence of cerebral infarction.Methods A total of 153 patients with acute cerebral infarction admitted to the Zhenjiang First People′s Hospital from January 2021 to February 2022 were selected.CD4^(+)/CD8^(+)T lymphocyte ratio of patients was determined,vascular stenosis score and collateral circulation filling score were evaluated by MRA.The patients were followed up for 1 year,including 34 patients with recurrent cerebral infarction as recurrent cerebral infarction group,107 patients without recurrent cerebral infarction as the non-recurrent cerebral infarction group,12 patients were excluded due to other causes of loss of follow-up,and the receiver operating characteristic(ROC)curve for using the indicators to predict the recurrent cerebral infarction was drawn.Results The CD4^(+)/CD8^(+)T lymphocyte ratio in recurrent cerebral infarction group was significantly higher than that in non-recurrent cerebral infarction group(P<0.05).Vascular stenosis score and collateral circulation filling score in recurrent cerebral infarction group were lower than those in non-recurrent cerebral infarction group(P<0.05).The recurrence of cerebral infarction was correlated with CD4^(+)/CD8^(+)T lymphocyte ratio,vascular stenosis score and collateral circulation filling score(P<0.05).ROC curve analysis showed that the area under the curve(AUC)of CD4^(+)/CD8^(+)T lymphocyte ratio,vascular stenosis score,and collateral circulation filling score to predict recurrent cerebral infarction was 0.975,0.889,and 0.935,respectively,and the AUC of recurrent cerebral infarction was 0.994 when combined with the three factors.The AUC of cerebral infarction recurrence was significantly higher than that of each index alone.Conclusion Serum CD4^(+)/CD8^(+)T lymphocyte ratio combined with MRA vascular stenosis score and collateral circulation filling score have high efficacy in the diagno
作者
刘娜
彭爱妮
吴晶
徐寿成
于明
LIU Na;PENG Aini;WU Jing;XU Shoucheng;YU Ming(Department of Neurology,Zhenjiang First People′s Hospital,Zhenjiang,Jiangsu 210031,China;Department of Neurology,Jiangbin Hospital Affiliated to Jiangsu University,Zhenjiang,Jiangsu 210031,China)
出处
《国际检验医学杂志》
CAS
2024年第2期199-203,共5页
International Journal of Laboratory Medicine
基金
江苏省卫生健康委科研项目(Z2021031)
江苏大学临床医学科技发展基金项目(JLY2021005)
镇江市第一人民医院院级科研基金(KFB2022002)。
