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脑心通胶囊联合多奈哌齐治疗老年血管性痴呆患者的效果

Effects of Naoxintong capsules combined with Donepezil in treatment of elderly patients with vascular dementia
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摘要 目的:观察脑心通胶囊联合多奈哌齐治疗老年血管性痴呆患者的效果。方法:选取2021年1—12月该院收治的100例老年血管性痴呆患者进行前瞻性研究,按照随机数字表法将其分为对照组和观察组各50例。对照组给予多奈哌齐治疗,观察组在对照组基础上联合脑心通胶囊治疗,比较两组治疗前后认知功能[蒙特利尔认知评估量表(MoCA)]评分、血液流变学指标(纤维蛋白原、血浆黏度、全血黏度、血细胞比容)水平、神经功能指标[同型半胱氨酸(Hcy)、神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白β(S100β)]水平及不良反应发生率。结果:治疗后,两组MoCA评分均高于治疗前,且观察组高于对照组,差异有统计学意义(P<0.05);两组纤维蛋白原、血浆黏度、全血黏度、血细胞比容水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组Hcy、NSE及S100β水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:脑心通胶囊联合多奈哌齐治疗老年血管性痴呆患者,可提高其认知功能,改善血液流变学指标水平,提高神经功能,效果优于单纯多奈哌齐治疗。 Objective:To observe effects of Naoxintong capsules combined with Donepezil in treatment of elderly patients with vascular dementia.Methods:A prospective study was conducted on 100 elderly patients with vascular dementia admitted to this hospital from January to December 2021.They were divided into control group and observation group according to the random number table method,50 cases in each group.The control group was treated with Donepezil,while the observation group was treated with Naoxintong capsules on the basis of the control group.The cognitive function[Montreal cognitive assessment scale(MoCA)]score,the hemorheology indexes(fibrinogen,plasma viscosity,whole blood viscosity,hematocrit)levels,the neurological function indexes[homocysteine(Hcy),neuron-specific enolase(NSE),S100 calcium binding proteinβ(S100β)]levels,and the incidence of adverse reactions were compared between the two groups before and after the treatment.Results:After the treatment,the MoCA scores of the two groups were higher than those before the treatment,that in the observation group was higher than that in the control group,and the difference was statistically significant(P<0.05).The levels of fibrinogen,plasma viscosity,whole blood viscosity and hematocrit in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The levels of Hcy,NSE and S100βin the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Naoxintong capsules combined with Donepezil in the treatment of the elderly patients with vascular dementia can improve their cognitive function,improve the levels of hemorheology indexes and improve the neurological function.Moreover,it is sup
作者 孟聪聪 MENG Congcong(Department of General Medical of Kaifeng Central Hospital,Kaifeng 475000 Henan,China)
出处 《中国民康医学》 2024年第1期103-105,共3页 Medical Journal of Chinese People’s Health
关键词 脑心通胶囊 多奈哌齐 血管性痴呆 认知功能 血液流变学 神经功能 不良反应 Naoxintong capsules Donepezil Vascular dementia Cognitive function Hemorheology Neurological function Adverse reaction
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