摘要
目的调查老年2型糖尿病(T2DM)患者肌肉减少症(简称“肌少症”)发病情况,分析影响跌倒风险的影响因素及合并肌功能降低与跌倒风险的关系。方法以该院2020年1月至2022年12月512例年龄≥60岁的T2DM患者为研究对象,采用CAMRY-EH101握力器测试握力(HS),秒表、皮尺测试行走速度(GS),生物电阻抗分析测定肌肉含量并计算骨骼肌质量指数(SMI);采用2019年亚洲老年肌少症管理机构(AWGS2019)标准对肌少症进行分组,摩尔斯跌倒风险预测量表评价跌倒风险,使用二元logistic回归分析跌倒风险的影响因素。结果研究对象肌少症检出率为19.92%,399例患者(77.93%)存在跌倒风险,而是否有肌少症及肌少症严重程度对跌倒风险无影响(P>0.05);非肌少症患者中,HS、GS、SMI下降组跌倒风险较正常组升高(P<0.001)。多因素分析结果显示,性别、BMI、血糖情况、白细胞介素6、T2DM视网膜病变、T2DM周围神经病变、T2DM血管病变7类变量是跌倒风险的影响因素(P<0.05)。结论老年T2DM患者跌倒风险较高,T2DM合并肌功能降低可加剧跌倒风险,但合并肌少症对跌倒风险无明显影响。
Objective To investigate the onset situation of sarcopenia in elderly patients with type 2 diabetes mellitus(T2DM),and to analyze the influence factors of fall risk and the relationship between the complicating muscle function reduction and the fall risk.Methods A total of 512 cases of T2DM aged≥60 years old in this hospital from January 2020 to December 2022 served as the study subjects.The grip strength(HS)was tested by the CAMRY-EH101 grip tester,the walking speed(GS)was measured by the stopwatch and tape measure,the muscle content was analyzed and determined by bioelectrical impedance.The skeletal muscle mass index(SMI)was calculated.Sarcopenia was grouped by the AWGS2019 standard,the Morse fall Risk Prediction Scale was used to evaluate the fall risk,and the influencing factors of fall risk were analyzed by binary logistic regression.Results The detection rate of sarcopenia among the study subjects was 19.92%,and 399 patients(77.93%)had the fall risk.Whether having sarcopenia or the severity of sarcopenia had no influence on the fall risk(P>0.05).Among the patients without sarcopenia,the fall risk in the HS,GS and SMI decrease group was increased compared with the normal group(P<0.001).The results of the multi-factor analysis showed that the 7 types of variables such as gender,BMI,blood glucose,IL-6,T2DM retinopathy,T2DM peripheral neuropathy and T2DM vascular disease were the influencing factors of fall risk(P<0.05).Conclusion Elderly patients with T2DM have a higher fall risk,and T2DM combined with decreased muscle function could aggravate the fall risk,but T2DM combined with sarcopenia has no significant effect on the fall risk.
作者
徐静
姜丽娜
史超
XU Jing;JIANG Lina;SHI Chao(Department of Endocrinology,First Affiliated Hospital,Xinjiang Medical University,Urumchi,Xinjiang 830054,China)
出处
《重庆医学》
CAS
2024年第1期73-78,共6页
Chongqing medicine
基金
新疆医科大学第一附属医院青年科研起航专项基金项目(2022YFY-QNRC-11)。
关键词
2型糖尿病
老年患者
肌肉减少症
跌倒
type 2 diabetes mellitus
elderly patients
sarcopenia
fall
