摘要
目的分析epstein-barr(EB)病毒感染、EB合并肺炎支原体(MP)、EB合并人巨细胞病毒(CMV)及EB同时合并MP、CMV感染所致传染性单核细胞增多症(IM)患儿的临床表现及其早期实验室检查相关指标的差异。方法选取2015年10月至2023年4月于成都市第二人民医院入院或初诊确诊为EB病毒检出阳性的IM患儿163例,并分为单纯EB病毒感染组、EB合并MP感染组、EB合并CMV感染组及EB合并MP+CMV感染组。收集患儿性别、年龄、临床症状及早期实验室各项相关指标,并进行统计学分析。结果4组性别、年龄、发热、扁桃体肿大、淋巴结肿大等发生率比较,差异无统计学意义(P>0.05)。单纯EB病毒感染组谷丙转氨酶(ALT)、谷草转氨酶(AST)及谷氨酰转肽酶(GGT)均高于EB合并MP感染组;GGT高于EB合并CMV感染组;ALT及GGT高于EB合并MP+CMV感染组(P<0.05)。结论IM患儿中单纯EB病毒感染者临床症状与EB合并感染者相似,但肝功能损害较EB合并感染者更严重,早期常规检测肝功能指标有助于临床早期诊治及预后。
Objective To analyze the different clinical manifestations and early laboratory risk for infectious mononucleosis(IM)in children caused by Epstein-Barr(EB)virus infection,EB virus infection combined with Mycoplasma pneumoniae(MP),EB virus infection combined with human cytomegalovirus(CMV)infection and EB virus infection combined with MP and CMV infection.Methods From October 2015 to April 2023,totally 163 children with IM patients and positive for EB virus who were admitted or first diagnosed in Chengdu Second People's Hospital were recruited.Among them,IM patients with EB virus infection were included in the experimental group,and those with EB virus infection combined with MP infection were included in the control group 1;those with EB virus infection combined with CMV infection were included in the control group 2;and those with EB virus infection combined with MP and CMV infection were included in the control group 3.Gender,age and clinical symptoms of children were collected,and the early laboratory indicators of infection were detected for statistical analyses.Results There were no significant differences in gender,age and incidence of clinical symptoms like fever,tonsil enlargement and lymph node enlargement among the four groups(P>0.05).Alanine aminotransferase(ALT),aspartate aminotransferase(AST)and glutamyl transpeptidase(GGT)of the experimental group were significantly higher than those of the control group 1(P<0.05).GGT of the experimental group was significantly higher than that of the control group 2(P<0.05).ALT and GGT of the experimental group were significantly higher than those of the control group 3(P<0.05).Conclusion The clinical symptoms of EB virus infection in children with IM are similar to those with the co-infection,but presenting severer liver function impairment.An early routine detection of risk factors for liver function favors early clinical diagnosis and treatment and thus improves the prognosis.
作者
聂芳
罗俊
Nie Fang;Luo Jun(Department of Medical Laboratory,Chengdu Second People's Hospital,Chengdu 610021,China)
出处
《临床荟萃》
2023年第11期1008-1011,共4页
Clinical Focus
基金
成都市科技局项目——NLRP3炎性小体轴调控焦亡在流感病毒感染后继发肺炎链球菌肺炎中的作用机制研究(2021-YF05-00521-SN)
成都市卫健委医学科研项目——HBP21通过线粒体自噬途径调控肝缺血再灌注损伤的作用和分子机制(2023233)。
关键词
传染性单核细胞增多症
疱疹病毒4型
人
巨细胞病毒
肺炎支原体
infectious mononucleosis
Epstein-Barr virus
human cytomegalovirus
mycoplasma pneumonia
risk indicators
