摘要
目的探究老年非小细胞肺癌患者实施胸腔镜肺癌根治术治疗的临床效果。方法400例老年非小细胞肺癌患者,根据治疗方法不同分为对照组和观察组,每组200例。对照组采用传统开胸术治疗,观察组采用胸腔镜肺癌根治术治疗。比较两组患者治疗前后肺功能指标[用力肺活量(FVC)、第1秒用力呼气容积(FEV1)、FEV1/FVC]、手术指标[鳞癌抗原(SCC)、癌胚抗原(CEA)、神经元特异性烯醇化酶(NSE)]、负面情绪[焦虑自评量表(SAS)、抑郁自评量表(SDS)评分]、生活质量及临床指标[手术时间、总出血量、引流管放置时间、总住院时间]、不良事件发生情况、临床效果。结果治疗后,两组患者FVC、FEV1、FEV1/FVC均高于本组治疗前,且观察组患者FVC(2.96±0.22)L、FEV1(1.92±0.97)L、FEV1/FVC(74.71±8.72)%高于对照组的(2.33±0.18)L、(1.47±0.59)L、(65.87±8.56)%,差异具有统计学意义(P<0.05)。两组患者SCC、CEA、NSE水平均低于本组治疗前,且观察组患者SCC(1.22±0.17)μg/L、CEA(4.14±0.53)μg/L、NSE(13.33±1.65)ng/ml均低于对照组的(2.03±0.36)μg/L、(7.12±1.55)μg/L、(15.78±2.33)ng/ml,差异具有统计学意义(P<0.05)。观察组患者手术时间(109.52±9.26)min、引流管放置时间(3.11±0.41)d、总住院时间(7.19±1.25)d短于对照组的(150.79±13.38)min、(5.09±0.82)d、(15.44±3.21)d,总出血量(120.32±10.12)ml少于对照组的(240.46±15.31)ml,差异具有统计学意义(P<0.05)。治疗后,两组患者SAS、SDS评分均低于本组治疗前,且观察组患者SAS评分(15.46±1.82)分、SDS评分(14.69±1.73)分低于对照组的(28.79±2.25)、(27.74±2.31)分,差异具有统计学意义(P<0.05)。观察组患者治疗期间不良事件发生率为5.00%,低于对照组的12.50%,差异具有统计学意义(P<0.05)。治疗后,两组患者生理功能、心理功能、社会功能、情绪功能评分均高于本组治疗前,且观察组患者高于对照组,差异具有统计学意义(P<0.05)。观察组
Objective To investigate the clinical effect of thoracoscopic radical resection of lung cancer in the clinical treatment of non-small cell lung cancer in the elderly.Methods A total of 400 elderly patients with non-small cell lung cancer were divided into a control group and an observation group according to different treatment methods,with 200 cases in each group.The control group was treated with traditional thoracotomy,and the observation group was treated with thoracoscopic radical resection of lung cancer.Both groups were compared in terms of lung function indexes[forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1/FVC],surgical indexes[squamous cell carcinoma antigen(SCC),carcinoembryonic antigen(CEA),neuron-specific enolase(NSE)],negative emotions[Self-rating Anxiety Scale(SAS),Self-rating Depression Scale(SDS)score],quality of life and clinical indicators[operative time,total blood loss,drainage tube indwelling time,total hospital stay]before and after treatment,occurrence of adverse events,and clinical effect.Results After treatment,FVC,FEV1 and FEV1/FVC in both groups were higher than those before treatment in this group;the observation group had FVC of(2.96±0.22)L,FEV1 of(1.92±0.97)L and FEV1/FVC of(74.71±8.72)%,which were higher than those of(2.33±0.18)L,(1.47±0.59)L and(65.87±8.56)%in the control group;the differences were statistically significant(P<0.05).The levels of SCC,CEA and NSE in both groups were lower than those before treatment in this group;the observation group had SCC of(1.22±0.17)μg/L,CEA of(4.14±0.53)μg/L and NSE of(13.33±1.65)ng/ml,which were lower than those of(2.03±0.36)μg/L,(7.12±1.55)μg/L and(15.78±2.33)ng/ml in the control group;the differences were statistically significant(P<0.05).In the observation group,the operative time was(109.52±9.26)min,the drainage tube indwelling time was(3.11±0.41)d,and the total hospital stay was(7.19±1.25)d,which were shorter than those of(150.79±13.38)min,(5.09±0.82)d and(15.44±3.21)d in the control g
作者
高佳
孙晨
陈博汉
GAO Jia;SUN Chen;CHEN Bo-han(Heze Municipal Hospital,Heze 274031,China)
出处
《中国实用医药》
2023年第24期1-6,共6页
China Practical Medicine
关键词
非小细胞肺癌
胸腔镜肺癌根治术
肺功能指标
负面情绪
生活质量
不良事件
临床效果
Non-small cell lung cancer
Thoracoscopic radical resection of lung cancer
Lung function index
Negative emotions
Quality of life
Adverse events
Clinical effects