摘要
综合分析国内外雷公藤研究相关文献,对雷公藤临床不良反应及肝毒性表现进行表述和总结,分析肝毒性产生的机制。通过雷公藤配伍单味中药、有效化学成分及中药复方及炮制加工降低肝毒性进行归纳,并分析其降低毒性机制,从而明确雷公藤肝毒性研究现状及不足,并进一步对雷公藤药材及成分降低毒性提高疗效发展提出建议,以期为雷公藤药材研究发展及临床安全有效使用提供参考。
By comprehensively analyzing the literature related to the study of Leigongteng(Tripterygium wilfordii)at home and abroad,the clinical adverse reactions and hepatotoxicity manifestations of T.wilfordii were expressed and summarized,and the mechanism of hepatotoxicity was analyzed.Through the drug matching of T.wilfordii with single Chinese medicine,effective chemical components,Chinese medicine compounds and processing to reduce liver toxicity,the mechanism of reducing toxicity was summarized and analyzed,so as to clarify the status and shortcomings of liver toxicity research of T.wilfordii,and further put forward suggestions on the development of reducing toxicity and improving efficacy of T.wilfordii,with view to providing reference for the research and development of T.wilfordii and its safe and effective clinical use.
作者
周国梁
宿树兰
华永庆
余黎
朱悦
段金廒
ZHOU Guo-liang;SU Shu-lan;HUA Yong-qing;YU li;ZHU Yue;DUAN Jin-ao(Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine,State Administration of Traditional Chinese Medicine Key Laboratory of Chinese Medicinal Resources Recycling Utilization,Nanjing University of Chinese Medicine,Nanjing 210023,China;College of Life and Health Science,Anhui Science and Technology University,Bengbu 233100,China)
出处
《中草药》
CAS
CSCD
北大核心
2023年第24期8263-8272,共10页
Chinese Traditional and Herbal Drugs
基金
国家自然科学基金资助项目(81973708)
南京中医药大学康缘学院创新创业项目(kyxysc19)
安徽科技学院校级自然项目(2021zryb22)
安徽省教育厅自然科研项目(KJ2021A0882)。
关键词
雷公藤
肝毒性
配伍
雷公藤甲素
雷公藤红素
雷公藤多苷
Tripterygium wilfordii Hook.f.
hepatotoxicity
compatibility of medicines
triptolide
tripterine
tripterygium glycosides
