摘要
目的 分析膝关节骨性关节炎患者血清可溶性生长刺激表达因子2(soluble growth stimulating express gene2, sST2)、骨硬化蛋白(sclerostin,SOST)表达水平及对患者疾病转归的影响。方法 将2021年5月至2022年5月陕西中医药大学附属医院收治的72例膝关节骨性关节炎患者纳入研究组,58例同期健康体检者纳入对照组。根据膝关节骨性关节炎患者疾病转归情况分为预后良好组(n=42)和预后不良组(n=30)。所有纳入对象入院后24 h内采用酶联免疫吸附法检测血清sST2、SOST表达水平。比较各组血清sST2、SOST表达水平。采用受试者工作特征曲线(receiver operator characteristic curve,ROC)评估血清sST2、SOST对膝关节骨性关节炎患者疾病转归的预测价值,同时采用单因素及多因素Logistic回归分析影响膝关节骨性关节炎患者疾病转归的相关因素。结果 研究组血清sST2水平高于对照组,血清SOST水平低于对照组(P<0.05)。预后不良组血清sST2水平高于预后良好组,血清SOST水平低于预后良好组(P<0.05)。ROC曲线分析结果显示,血清sST2曲线下面积为0.768,截断值为33.6 ng/mL,灵敏度以及特异性分别为91.66%、59.62%;血清SOST曲线下面积为0.859,截断值为26.8 pg/mL,灵敏度以及特异性分别为92.67%、65.22%;二者联合曲线下面积为0.902,灵敏度以及特异性分别为87.33%、86.64%。多因素Logistic回归分析发现,K-L分级及血清sST2、SOST均为影响膝关节骨性关节炎患者疾病转归的危险因素(OR>1,P<0.05)。结论 膝关节骨性关节炎患者血清sST2水平升高,SOST表达水平降低,且二者表达水平与疾病转归密切相关,均是影响患者疾病转归的独立危险因素。
Objective To analyze the serum levels of soluble growth stimulating factor 2(sST2)and sclerostin(SOST)in patients with knee osteoarthritis and their effects on the prognosis of the disease.Methods A total of 72 patients with osteoarthritis of knee from May 2021 to May 2022 were enrolled in the study group,and 58 healthy controls were enrolled in the control group.Patients with knee osteoarthritis were divided into good prognosis group(n=42)and bad prognosis group(n=30).Serum levels of sST2 and SOST were measured by enzyme linked immunosorbent assay(ELISA)within 24 h after admission.The expression levels of sST2 and SOST in serum of each group were compared.Receiver operating characteristic curve(ROC)was used to assess the predictive value of serum sST2 and SOST for the outcome of knee osteoarthritis,univariate and multivariate logistic regression analysis was used to analyze the factors related to the outcome of knee osteoarthritis.Results The serum level of sST2 was higher and the serum level of SOST was lower in the study group than in the control group(P<0.05).The serum level of sST2 in the poor prognosis group was higher than that in the good prognosis group,and the serum level of SOST was lower than that in the good prognosis group(P<0.05).The results of ROC curve analysis showed that the area under the curve of serum sST2 was 0.768,the cut-off value was 33.6 ng/mL,the sensitivity and specificity were 91.66%and 59.62%,respectively.The area under the curve of serum SOST was 0.859,the cut-off value was 26.8 pg/mL,the sensitivity and specificity were 92.67%and 65.22%,respectively.The area under the curve of serum SOST combined with serum sST2 was 0.902,and the sensitivity and specificity were 87.33%and 86.64%,respectively.Multivariate Logistic regression analysis showed that K-L grade,serum sST2 and SOST were risk factors for the outcome of knee osteoarthritis/osteodystrophy disease(OR>1,P<0.05).Conclusion The serum levels of sST2 and SOST in patients with knee osteoarthritis are significantly higher than those
作者
赵文勇
雷雨欣
孙智平
仇永锋
ZHAO Wenyong;LEI Yuxin;SUN Zhiping;QIU Yongfeng(Affiliated Hospital of Shaanxi University of Chinese Medicine,Xianyang 712000,China)
出处
《延安大学学报（医学科学版）》
2023年第4期44-47,53,共5页
Journal of Yan'an University:Medical Science Edition
基金
陕西省中医药管理局(2021-ZZ-ZC002)
2021年省教育厅项目(303-1730102098)
咸阳市科技成果推广计划(2018KT-50)。
