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吸烟对新型冠状病毒感染的促进作用和相关机制 被引量:1

Contribution of tobacco smoking to the risk of novel coronavirus infection and related mechanisms
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摘要 新型冠状病毒及其变种仍然在全球广泛传播,疫苗可以降低死亡率但无法清除病毒感染风险。鉴别和保护高危易感人群对防控新型冠状病毒及其他冠状病毒的感染仍然具有重大意义。吸烟是多种呼吸道疾病的重要危险因素,因此也可能影响新型冠状病毒感染(COVID-19)风险以及感染后疾病的转归。本文综述烟草暴露与COVID-19相关的流行病学证据和机制研究证据,总结烟草暴露对COVID-19感染、重症以及死亡风险的促进作用,并且分析烟草暴露通过调控炎症微环境与基因表达进而影响新型冠状病毒致病的分子机制。 The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants are still globally spreading.Vaccines can reduce the mortality,but cannot eliminate the risk of infection.The identification and protection of the high-risk susceptible population remains of great importance for the prevention and control of SARS-CoV2 and other coronavirus infections.Smoking is an important risk factor for many respiratory diseases,and therefore may also influence the risk of SARS-CoV2 infection and the disease progression after infection.This study reviewed the epidemiological and mechanistic evidence supporting the relationship between tobacco exposure and SARS-CoV2 infection,summarized the contributing effects of tobacco exposure to the infection risk,disease severity,and mortality of COVID-19,and analyzed the molecular mechanisms by which cigarette smoking affects COVID-19 through regulating inflammatory microenvironment and gene expression.
作者 郭芮希 凌劲涛 王柏栋 刘文斌 曹广文 GUO Ruixi;LING Jintao;WANG Bodong;LIU Wenbin;CAO Guangwen(College of Basic Medical Sciences,Naval Medical University,Shanghai 200433,China;Department of Epidemiology,Naval Medical University,Shanghai Key Laboratory of Medical Bioprotection,Key Laboratory of Biological Defense,Ministry of Education,Shanghai 200433,China)
出处 《上海预防医学》 2023年第11期1153-1156,1161,共5页 Shanghai Journal of Preventive Medicine
基金 国家自然科学基金新冠专项项目(82041022) 上海市卫生健康委员会青年课题(20204Y0304)。
关键词 吸烟 新型冠状病毒 病毒感染 流行病学 分子机制 smoking SARS-CoV-2 viral infection epidemiology molecular mechanism
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