摘要
目的 探讨砂半理中汤加味治疗新型冠状病毒奥密克戎变异株感染“长阳”患者(简称“长阳”患者)的临床疗效与安全性。方法 选取2022年11月14日至12月14日就诊于重庆市江北区石子山方舱医院的“长阳”患者184例,按Excel随机函数法分为试验组和对照组。最终纳入169例,其中试验组85例,对照组84例。对照组患者给予中药汤剂协定方治疗,试验组患者在对照组治疗基础上加用砂半理中汤加味治疗。两组患者均给药至连续2次新型冠状病毒核酸检测呈阴性,采样时间间隔24 h。结果 试验组总有效率为92.94%,显著高于对照组的82.14%(P <0.05);治疗后,两组患者中医证候量表主要症状、次要症状评分及总分均显著降低(P <0.05),且试验组均显著低于对照组(P <0.05);试验组患者2次核酸平均转阴时间均显著短于对照组(P <0.05);对照组和试验组分别出现腹泻1例和2例,对症处理后均好转。结论 砂半理中汤加味治疗“长阳”患者的临床疗效良好,可缩短“长阳”患者的核酸转阴时间,改善临床症状,且安全性良好。
Objective To investigate the clinical efficacy and safety of Shabanlizhong Decoction in the treatment of long-lasting nucleic acid test(NAT)-positive patients(hereinafter referred to as long-lasting positive patients)infected with Omicron variant of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Methods A total of 184 long-lasting positive patients who visited Shizishan Fangcang Hospital in the Jiangbei District,Chongqing from November 14 to December 14,2022 were selected and randomly divided into the test group and the control group by the Excel random function.Finally,169 cases were included,including 85 cases in the test group and 84 cases in the control group.The patients in the control group were treated with traditional Chinese medicine decoction protocol,on this basis,the patients in the test group were treated with modified Shabanlizhong Decoction.The patients in the two groups were treated until they tested negative for SARS-CoV-2 NAT twice with a sampling interval of 24 h.Results The total effective rate in the test group was 92.94%,which was significantly higher than 82.14%in the control group(P<0.05).After treatment,the single scores and total score of main symptoms and secondary symptoms of the traditional Chinese medicine syndrome scale in the two groups significantly decreased(P<0.05),and those in the test group were significantly lower than those in the control group(P<0.05).The average time for two NATs to turn negative in the test group was significantly shorter than that in the control group(P<0.05).There was one case of diarrhea in the control group and two cases in the test group,which improved after symptomatic treatment.Conclusion The modified Shabanlizhong Decoction has good clinical efficacy and safety in the treatment of long-lasting positive patients,which can shorten the time for nucleic acid to turn negative,and improve clinical symptoms.
作者
陈勇
曹晋
姚秋菊
南瑞雪
何德英
任毅
CHEN Yong;CAO Jin;YAO Qiuju;NAN Ruixue;HE Deying;REN Yi(Chongqing Hospital of Traditional Chinese Medicine,Chongqing,China 400021;Graduate School,Chengdu University of Traditional Chinese Medicine,Chengdu,Sichuan,China 610075)
出处
《中国药业》
CAS
2024年第1期91-94,共4页
China Pharmaceuticals
基金
重庆市教育委员会科学技术研究计划项目[KJZD-K202215103]
成都中医药大学2022年度“杏林学者”医院专项[YYZX2022129]。
