摘要
炎症性肠病(IBD)表现为反复发作的非特异性肠道炎症反应,肠纤维化是IBD并发肠梗阻的重要原因。核因子E2相关因子2(Nrf2)是细胞内具有抗氧化应激反应的转录因子。在IBD中,Nrf2及其下游调控的抗氧化酶通过抑制核因子⁃κB激活、调节肠道免疫辅助性T细胞17/调节性T细胞平衡、抑制转化生长因子⁃β1/Smads信号通路等方式实现抗肠纤维化的保护作用。本文就Nrf2结构,Nrf2在IBD中发挥抗肠纤维化的具体作用机制,以及近年来通过Nrf2途径治疗IBD的相关研究进行综述,试图为IBD肠纤维化防治提供新方向。
Inflammatory bowel disease(IBD)is characterized by recurrent non⁃specific intestinal inflammatory responses.Intestinal fibrosis is an important cause of IBD complicated with intestinal obstruction.Nuclear factor erythroid 2⁃related factor 2(Nrf2)is a transcription factor that has anti⁃oxidative stress response in cells.In IBD,Nrf2 and its downstream regulated antioxidant enzymes achieve protective effects against intestinal fibrosis by inhibiting the activation of nuclear factor⁃κB,regulating T helper cell 17/regulatory T cell balance of intestinal immunity,and inhibiting transforming growth factor⁃β1/Smads signaling pathway.In this review,the structure of Nrf2,the specific mechanism of Nrf2's effect on intestinal fibrosis in IBD,and the recent studies on the treatment of IBD through Nrf2 pathway were reviewed in an attempt to provide a new direction for the prevention and treatment of IBD.
作者
范梦磊
陈可
鲍文扬
杨舒凡
陶瑞
王小云
FAN Menglei;CHEN Ke;BAO Wenyang;YANG Shufan;TAO Rui;WANG Xiaoyun(Department of Gastroenterology,Wuxi Clinical College of Nantong University,Wuxi,Jiangsu Province214002)
出处
《胃肠病学》
北大核心
2023年第3期186-190,共5页
Chinese Journal of Gastroenterology
基金
无锡市医学创新团队建设(胃肠病学)(CXTD2021020)
无锡市“双百”中青年医疗卫生拔尖人才(BJ2020024)。
关键词
炎症性肠病
核因子E2相关因子2
肠纤维化
炎症
氧化性应激
Inflammatory Bowel Disease
Nuclear Factor Erythroid 2⁃Related Factor 2
Intestinal Fibrosis
Inflammation
Oxidative Stress
