摘要
凝血酶原复合物(PCC)是以维生素K依赖性凝血因子为主要成分的血液制品。虽然PCC已在临床应用70多年,安全性已得到明显提升,且已经广泛应用于重症患者凝血功能障碍或大出血的治疗,但若使用方法不当,可能会减弱止血效果或增加血栓形成的风险。为了规范PCC的合理使用,中国医药教育协会血栓与止血危重病专业委员会、全军重症医学专业委员会及中国研究型医院学会血栓与止血专业委员会组织制定此专家共识,包括定义、适应证、监测与评价等3个部分,共10条建议,旨在帮助临床医师合理使用PCC,以提高重症患者救治水平。
The prothrombin complex concentrate(PCC)is a blood product that mainly contains vitamin K-dependent coagulation factors.PCC has been used clinically for more than 70 years,and its safety has been significantly improved.It has been widely used in the treatment of coagulation disorders or severe bleeding in critically ill patients.If used improperly,it may weaken the hemostatic effect or increase the risk of thrombosis.In order to standardize the rational use of PCC,Chinese Society of Thrombosis,Hemostasis and Critical Care,Chinese Medicine Education Association,People's Liberation Army Professional Committee of Critical Care Medicine,Chinese Society of Thrombosis and Hemostasis,Chinese Research Hospital Association have organized the formulation of this expert consensus,including three parts:definition,indications,and monitoring and evaluation of efficacy,with a total of 10 suggestions,aiming to help clinicians reasonably use PCC and improve the treatment in critical illness.
作者
宋景春
王岗
房云海
吴海鹰
尹海燕
张进华
柯路
丁仁彧
周洲
中国医药教育协会血栓与止血危重病专业委员会
全军重症医学专业委员会
中国研究型医院学会血栓与止血专业委员会
Song Jing-Chun;Wang Gang;Fang Yun-Hai;Wu Hai-Ying;Yin Hai-Yan;Zhang Jin-Hua;Ke-Lu;Ding Ren-Yu;Zhou Zhou;Chinese Society of Thrombosis,Hemostasis and Critical Care,Chinese Medicine Education Association;People's Liberation Army Professional Committee of Critical Care Medicine;Chinese Society of Thrombosis and Hemostasis,Chinese Research Hospital Association(Department of Critical Care Medicine,the 908th Hospital of Joint Logistics Support Forces of Chinese PLA,Nanchang,Jiangxi 330002,China;Department of Critical Care Medicine,the Second Affiliated Hospital of Xi'an Jiaotong University,Xi'an,Shaanxi 710004,China;Hemophilia Diagnosis and Treatment Center,Shandong Blood Center,Jinan,Shandong 250013,China;Emergency Department,the First Affiliated Hospital of Kunming Medical University,Kunming,Yunnan 650032,China;Department of Critical Care Medicine,the First Affiliated Hospital of Jinan University,Guangzhou,Guangdong 510630,China;Pharmacy Department,Fujian Provincial Maternity and Child Health Hospital,Fuzhou,Fujian 350005,China;Department of Critical Care Medicine,General Hospital of Eastern Theater Command,Nanjing,Jiangsu 210002,China;Department of Critical Care Medicine,the First Affiliated Hospital of Chinese Medical University,Shenyang,Liaoning 110001,China;Department of Laboratory Medicine,Fuwai Hospital,Chinese Academy of Medical Sciences,Beijing 100037,China;不详)
出处
《解放军医学杂志》
CAS
CSCD
北大核心
2023年第12期1359-1369,共11页
Medical Journal of Chinese People's Liberation Army
关键词
凝血酶原复合物
血液凝固因子
危重病
出血
prothrombin complex concentrate
blood coagulation factors
critical illness
hemorrhage
