摘要
目的 调查连云港地区泌尿生殖系统支原体感染情况和耐药性变迁,为临床合理用药提供依据。方法 收集2015—2022年连云港市妇幼保健院疑似泌尿生殖道支原体感染的病例22 889例,回顾性分析临床资料,统计生殖道支原体感染情况和药敏结果。结果 生殖道支原体阳性标本8 943例,其中解脲脲原体(Uu)感染率最高,为33.64%(7 700/22 889),明显高于人型支原体(Mh)感染率3.91%(894/22 889)和混合(Uu+Mh)型感染率1.52%(349/22 889),差异具有统计学意义(P<0.05)。2015—2022年总体感染率和Uu感染率呈增长趋势。女性泌尿生殖道支原体感染率为42.42%,显著高于男性的22.47%(χ^(2)=534.21,P<0.05);与小于20岁以及40岁以上年龄段人群相比,20~40岁人群感染率最高,达到40.84%(6 108/14 955)。泌尿生殖道支原体对强力霉素、美满霉素及交沙霉素敏感性较高,耐药率均未超过5.00%;Uu感染者对红霉素、氧氟沙星和环丙沙星的耐药率有增长趋势(P<0.05),Mh感染者对红霉素、罗红霉素、阿奇霉素和氧氟沙星的耐药率有增长趋势(P<0.05)。结论连云港地区泌尿生殖道支原体感染率呈逐年增长趋势,需加强相应的监控;强力霉素、美满霉素和交沙霉素适合作为本地区泌尿生殖道支原体感染治疗的首选临床用药,大部分喹诺酮类药物的耐药率较高,提示存在该类药物滥用情况,需加强临床监管。
Objective To investigate the infection status and drug resistance of urogenital tract mycoplasma in Lianyungang district,Jiangsu.Methods Based on retrospective collection of 22889 cases of suspected mycoplasma genital infection in Lianyungang Maternity and Child Health Hospital from 2015 to 2022,the infection and drug resistance rate of genital mycoplasma were analyzed.Results A total of 8943 genital mycoplasma positive specimens were detected.Among them,the infection rate of Ureaplasma urealyticum(Uu)was the highest,accounting for 33.64%(7700/22889),which was significantly higher than that of Mycoplasma hominis(Mh),3.91%(894/22889),and that of mixed(Uu+Mh)type,1.52%(349/22889).The difference was statistically significant(P<0.05).The infection rates of genital mycoplasma and Uu showed increasing trend from 2015 to 2022.The overall infection rates of genital mycoplasma in females were 42.42%,which was significantly higher than that in males of 22.47%.The highest infection rate of 40.84%(6108/14955)was found in the group of 20 to 40 years old as compared to those younger than 20 years old as well as those over 40 years old.The genital mycoplasma was highly sensitive to doxycycline,minocycline and josamycin,and the drug resistance rate was lower than 5.00%.From 2015 to 2022,there was an increasing trend of resistance rates to erythromycin,ofloxacin and ciprofloxacin in Uuinfected patients(P<0.05)and erythromycin,roxithromycin,azithromycin and ofloxacin in Mhinfected patients(P<0.05).Conclusion The incidence of urogenital tract mycoplasma infection in Lianyungang district shows a gradual increase for recent years.Doxycycline,minocycline and josamycin are suitable as the first choice for the treatment of genital mycoplasma infection.Most quinolone drugs have shown high resistance rate,indicating that this type of drugs are possibly overused.The strengthened relevant monitoring of antibacterial drugs should be necessary.
作者
王震文
张鹏飞
周保成
WANG Zhenwen;ZHANG Pengfei;ZHOU Baocheng(Department of Laboratory Medicine,Lianyungang Maternal and Child Health Hospital,Lianyungang 222000,Jiangsu,China)
出处
《临床检验杂志》
CAS
2023年第10期793-798,共6页
Chinese Journal of Clinical Laboratory Science
关键词
解脲脲原体
人型支原体
药敏试验
Ureaplasma urealyticum
Mycoplasma hominis
drug susceptibility test
